乳腺癌MRI征像与人类表皮生长因子受体2、ER、PR表达的相关性  

Correlation between the expressions of the estrogen receptor,progesterone receptor and human epidermal growth factor receptor 2 of patients with breast cancer and their magnetic resonance imaging(MRI)signs

作　　者：高洋 王鹏飞 姚雷 丁建峰 GAO Yang;WANG Pengfei;YAO Lei;DING Jianfeng(Yuncheng Central Hospital,Yuncheng,Shanxi Province,044000)

机构地区：[1]山西省运城市中心医院,044000

出　　处：《中国计划生育学杂志》2024年第4期948-952,共5页Chinese Journal of Family Planning

基　　金：山西省科协健康科普课题项目(JKKP202115)。

摘　　要：目的:探索雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(Her2)表达与乳腺癌磁共振成像(MRI)征像的相关性。方法:回顾性分析2021年1月-2022年12月于本院行乳腺癌手术患者125例临床资料,均于月经后1~2周行MRI检查,由2名专业副主任医师根据MRI图像对病灶组织进行诊断分析MRI征像,包括肿瘤直径、肿瘤形态、强化方式、肿瘤边缘、早期强化率、时间-信号强度曲线(TIC)。采用免疫组织化学SP法检查肿瘤组织中ER、PR、Her2表达。结果:MRI检查,不同肿瘤直径、边缘、形态和TIC的患者PR阳性表达率存在差异,不同肿瘤形态、TIC的患者ER阳性表达率存在差异(均P<0.05);其余不同MRI征像患者ER、PR、Her2阳性表达率未见差异(P>0.05)。肿瘤边缘与ER、Her2阳性表达均呈负相关性(P<0.05),早期强化方式与Her2阳性表达负相关性(P<0.05),其余MRI征像与ER、PR、Her2阳性表达率无明显相关性(P>0.05)。结论:ER、PR、Her2与乳腺癌MRI征像如肿瘤直径、形态、边缘、强化方式等存在相关性。乳腺癌MRI征像可作为乳腺癌组织病理学变化的初步评估,为临床乳腺癌患者的诊治和预后评估提供参考。Objective:To explore the correlation between the expressions of the estrogen receptor(Er),progesterone receptor(Pr)and human epidermal growth factor receptor 2(Her2)of patients with breast cancer and their magnetic resonance imaging(MRI)signs.Methods:The clinical data of 125patients with breast cancer who had been operated in hospital from January 2021 to December 2022 were analyzed retrospectively.These patients underwent MRI examination in 1 to 2 weeks after menstruation.The MRI signs of the lesions of the patients were analyzed and diagnosed by two associate chief physicians according to the results of MRI examination of the patients.The MRI signs included the tumor diameter,the tumor morphology,the enhancement pattern,the tumor margin,the early enhancement rate and the time-signal intensity curve(TIC).The expressions of the ER,PR and Her2 in tumor tissues were detected by immunohistochemical SPmethod.Results:The MRI examination showed that the positive expression rate of PR of the patients was different among the patients with different tumor diameter,margin,shape or TIC,and the positive expression rate of ER of the patients was different among the patients with different tumor morphology or TIC(all P<0.05).There was no significant difference in the positive expression rates of ER,PR and Her2 among the patients with different other MRI signs(P>0.05).The tumor margin of MRI signs of the patients was negatively correlated with their ER and Her2 positive expressions(P<0.05),and the early enhancement pattern of the patients was negatively correlated with their Her2 positive expression(P<0.05).The other MRI signs of the patients had no significant correlation with the positive expression rates of their ER,PR and Her2(P>0.05).Conclusion:The levels of the ER,PR and Her2 of the patients are correlated with their MRI signs of the breast cancer,such as the tumor diameter,the tumor morphology,the tumor margin and the enhancement pattern.The MRI features of the breast cancer of the patients can be used as the preliminary

关 键 词：乳腺癌 人类表皮生长因子受体2 雌激素受体 孕激素受体 磁共振成像 相关性 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]