七失神同源物2、血小板衍生生长因子-BB在乳腺浸润性导管癌中的表达及意义  

Expression and significance of seven in absentia homolog and platelet-derived growth factor-BB in breast invasive ductal carcinoma

作　　者：朱永前[1] 刘晓峰[1] 齐宇 Zhu Yongqian;Liu Xiaofeng;Qi Yu(Department of Pathology,Lu'an Hospital of Traditional Chinese Medicine,Lu'an 237005,China)

机构地区：[1]六安市中医院病理科,六安237005

出　　处：《中国医师进修杂志》2024年第4期371-374,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的分析七失神同源物2(SIAH2)、血小板衍生生长因子-BB(PDGF-BB)在乳腺浸润性导管癌中的表达及意义。方法回顾性选取2018年6月至2022年6月在六安市中医院接受手术治疗的96例乳腺浸润性导管癌患者作为研究对象,收集患者癌组织标本和癌旁组织标本(距肿瘤组织至少5 cm),比较乳腺癌组织和癌旁组织SIAH2、PDGF-BB表达水平,采用Spearman检验分析乳腺癌组织中SIAH2、PDGF-BB表达的相关性,并分析SIAH2、PDGF-BB表达与临床病理学参数的关系。结果乳腺癌组织SIAH2、PDGF-BB阳性表达率高于癌旁组织[72.92%(70/96)比9.38%(9/96)、56.25%(54/96)比11.46%(11/96)],差异有统计学意义(χ^(2)=80.03、43.01,P<0.01)。乳腺癌组织中SIAH2和PDGF-BB表达具有相关性(r=0.425,P<0.05);并且组织学分级越高,SIAH2、PDGF-BB阳性表达率越高(P<0.05);雌激素受体(ER)、孕激素受体(PR)阳性患者SIAH2、PDGF-BB阳性表达率高于ER、PR阴性患者[91.38%(53/58)比44.74%(17/38)、90.16%(55/61)比42.86%(15/35)、81.03%(47/58)比18.42%(7/38)、72.13%(44/61)比28.57%(10/35)](P<0.05)。结论乳腺浸润性导管癌组织中SIAH2、PDGF-BB阳性表达与组织学分级有关,其可能参与了乳腺癌的发生、侵袭和转移过程的调控。Objective To analyze the expression and significance of seven in absentia homolog(SIAH)and platelet-derived growth factor-BB(PDGF-BB)in breast invasive ductal carcinoma.Methods A total of 96 patients with breast invasive ductal carcinoma who underwent surgical treatment in Lu′an Hospital of Traditional Chinese Medicine from June 2018 to June 2022 were selected as the research objects.The expressions of SIAH2 and PDGF-BB in breast cancer tissues and adjacent tissues were compared,and the correlation between SIAH2 and PDGF-BB expression in breast cancer tissues was analyzed by Spearman correlation.The relationship between SIAH2,PDGF-BB expression and clinicopathological parameters in breast invasive ductal carcinoma was analyzed.Results The positive expressions of SIAH2 and PDGF-BB in breast cancer tissues were significantly higher than those in adjacent tissues:72.92%(70/96)vs.9.38%(9/96),56.25%(54/96)vs.11.46%(11/96),there were statistical differences(χ^(2)=80.03,43.01,P<0.01).The expression of SIAH2 and PDGF-BB in breast cancer tissues was correlated(r=0.425,P<0.05).In patients with breast invasive ductal carcinoma,the higher the histological grade,the higher the positive expression of SIAH2 and PDGF-BB(P<0.05).The positive expression of SIAH2 and PDGF-BB in patients with positive of estrogen receptor(ER)and progesterone receptor(PR)were higher than those in patients with negative ER and PR:91.38%(53/58)vs.44.74%(17/38),90.16%(55/61)vs.42.86%(15/35);81.03%(47/58)vs.18.42%(7/38),72.13%(44/61)vs.28.57%(10/35),P<0.05.Conclusions The positive expressions of SIAH2 and PDGF-BB in breast invasive ductal carcinoma are significantly higher,which are related to histological grade,and may be involved in the regulation of the occurrence,invasion and metastasis of breast cancer.

关 键 词：乳腺肿瘤 病理状态 体征和症状 七失神同源物 血小板衍生生长因子-BB 

分 类 号：R737.9[医药卫生—肿瘤]