非小细胞肺癌合并胸腔积液患者留置导管时间及其相关因素分析  

Analysis of catheter indwelling time and related factors in patients with non-small cell lung cancer complicated with pleural effusion

作　　者：林卫佳 袁胜芳 李峰 项保利[1] LIN Weijia;YUAN Shengfang;LI Feng;XIANG Baoli(Department of Respiratory and Critical Care Medicine,First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)

机构地区：[1]河北北方学院附属第一医院呼吸与危重症医学科,河北张家口075000

出　　处：《临床肺科杂志》2024年第5期717-721,共5页Journal of Clinical Pulmonary Medicine

基　　金：河北省医学科学研究课题计划项目(No.20200525);河北省张家口市重点研发计划项目(No.2021046D)。

摘　　要：目的 探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)合并胸腔积液患者留置导管时间及相关因素。方法 选取2020年1月至2022年10月我院NSCLC合并胸腔积液患者240例为研究对象。记录成功移除胸腔导管患者胸腔导管留置时间,并根据胸腔导管留置中位时间分为A组和B组,对比两组一般资料、治疗前胸腔积液情况及实验室资料,同时采用多元线性回归分析模型分析影响NSCLC合并胸腔积液患者留置导管时间的相关因素。结果 植入胸腔导管后的240例NSCLC合并胸腔积液患者中,30例由于不明原因或患者随访而丢失,46例因继发性胸膜炎而终止,最终164例患者成功拔除胸腔导管,管道留置时间18(15,21)d,将导管留置时间<18d为A组(n=77),导管留置时间≥18d为B组(n=87)。A组吸烟史占比、治疗前胸腔积液量、胸腔积液乳酸脱氢酶(Lactate Dehydrogenase,LDH)水平低于B组,放化疗、美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)评分≤2分占比高于B组(P<0.05);多因素线性回归分析显示,吸烟史、胸腔积液量、LDH正向影响NSCLC合并胸腔积液患者留置导管时间(B=3.320,B=0.003,B=0.011,P<0.05),ECOG评分≤2分、放化疗负向影响NSCLC合并胸腔积液患者留置导管时间(B=-1.559,B=-0.971,P<0.05)。结论 NSCLC合并胸腔积液患者留置导管时间与ECOG评分、吸烟、放化疗、胸腔积液量、胸腔积液LDH水平有关。临床医生在判断留置胸腔导管是否是治疗NSCLC合并胸腔积液的理想方法时,应考虑影响胸腔导管留置时间的影响因素。Objective To investigate the duration of catheter indwelling and related factors in patients with non-small cell lung cancer(NSCLC) complicated with pleural effusion.Methods A total of 240 patients with NSCLC complicated with pleural effusion in our hospital from January 2020 to October 2022 were selected as the research objects.The thoracic catheter indwelling time of patients with thoracic catheter removal was recorded,and the patients were divided into group A and group B according to the bipartile number of thoracic catheter indwelling time.The general data,the condition of pleural effusion before treatment,and laboratory data of the two groups were compared.Meanwhile,the multiple linear regression analysis model was used to analyze the related factors affecting the catheter indwelling time of patients with NSCLC complicated with pleural effusion.Results Among the 240 patients with NSCLC complicated with pleural effusion after implantation,30 cases were lost due to unknown reasons or patient follow-up,and 46 cases were terminated due to secondary pleurisy.Finally,the thoracic catheterization was successfully removed in 164 patients,and the catheter retention time was 18(15,21) days,and the catheter retention time <18d was group A(n=77).The catheter indwelling time ≥18 d was in group B(n=87).The smoking history,pleural effusion volume before treatment,and Lactate Dehydrogenase(LDH) level of pleural effusion were lower in Group A than those in Group B.The proportion of ECOG score ≤2 points was higher than that of group B(P<0.05).Multiple linear regression analysis showed that smoking history,pleural effusion volume,and LDH positively affected catheter indentation time in NSCLC patients with pleural effusion(β=3.320,β=0.003,β=0.011,P<0.05).ECOG score ≤2 points and chemoradiotherapy negatively affected catheter indwelling time in NSCLC patients with pleural effusion(β=-1.559,β=-0.971,P<0.05).Conclusion The duration of catheter indwelling in NSCLC patients with pleural effusion was related to ECOG score

关 键 词：非小细胞肺癌 胸腔积液 留置导管时间 放化疗 

分 类 号：R734.2[医药卫生—肿瘤]