原发性肝癌患者血清PIVKA-Ⅱ、AFP表达水平及其临床意义  

Expression of serum PIVKA-Ⅱand AFP levels in patients with primary liver cancer and their clinical significance

作　　者：卓晓娅 陈礼好 黄定蒙 ZHUO Xiaoya;CHEN Lihao;HUANG Dingmeng(Cangnan County third people's Hospital,Zhejiang 325804,China)

机构地区：[1]浙江省苍南县第三人民医院,苍南325804 [2]温州医科大学附属苍南医院

出　　处：《浙江创伤外科》2024年第4期622-624,628,共4页Zhejiang Journal of Traumatic Surgery

摘　　要：目的探讨原发性肝癌患者血清维生素K缺乏或拮抗剂-Ⅱ诱导的蛋白质(PIVKA-Ⅱ)、甲胎蛋白(AFP)水平变化及其临床意义。方法回顾性分析温州医科大学附属苍南医院2019年1月至2023年10月接诊的68例原发性肝癌患者的临床资料,作为肝癌组,并选择同期接诊的50例乙型肝炎肝硬化患者作为肝硬化组、50例慢性乙型肝炎患者作为肝炎组、50例健康人群作为对照组。比较四组血清PIVKA-Ⅱ、AFP水平,比较肝癌组不同病理特征患者血清PIVKA-Ⅱ、AFP水平。结果肝癌组血清PIVKA-Ⅱ、AFP水平均高于肝硬化组、肝炎组及对照组,有统计学意义(P<0.05),肝硬化组、肝炎组、对照组血清PIVKA-Ⅱ比较,无统计学意义(P>0.05),肝硬化组、肝炎组血清AFP比较,无统计学意义(P>0.05);肝癌组不同TNM分期、肝功能Child分级、肿瘤直径、病灶数量、淋巴结转移、微血管侵犯患者比较,均有统计学意义(P<0.05)。结论原发性肝癌患者血清PIVKA-Ⅱ、AFP均明显升高,可反映患者病情程度,有较好的临床应用价值。Objective To study the serum Protein Induced by Vitamin K Absence or Antagonist-Ⅱ(PIVKA-Ⅱ)and Alpha-fetoprotein(AFP) levels in patients with primary liver cancer and their clinical significance.Methods The clinical data of 68 patients with primary liver cancer admitted to our hospital from January 2019 to October 2023 were analyzed as the liver cancer group,and 50 patients with hepatitis B cirrhosis admitted during the same period were selected as the cirrhosis group,50 patients with chronic hepatitis B as the hepatitis group,and 50 healthy people as the control group.The serum PIVKA-Ⅱand AFP levels in the four groups were compared,and serum PIVKA-Ⅱand AFP levels in patients with different pathological characteristics in the liver cancer group were compared.Results The serum PIVKA-Ⅱand AFP levels in liver cancer group were higher than those in cirrhosis group,hepatitis group and control group,with statistical significance(P<0.05).There was no statistical significance in serum PIVKA-Ⅱbetween cirrhosis group,hepatitis group and control group(P>0.05),and there was no significant difference in serum AFP between cirrhosis group and hepatitis group(P>0.05).Comparison of patients with different TNM stage in liver cancer group,liver function Child grade,tumor diameter,number of lesions,lymph node metastasis and microvascular invasion in HCC group,there was statistical significance(P<0.05).Conclusion Serum PIVKA-Ⅱand AFP were significantly increased in patients with primary liver cancer,which could reflect the severity of the pa-tient's disease and have good clinical application value.

关 键 词：原发性肝癌 维生素K缺乏或拮抗剂-Ⅱ诱导的蛋白质 甲胎蛋白 病理特征 

分 类 号：R735.7[医药卫生—肿瘤]