Rutaecarpine ameliorates imiquimod-induced psoriasis-like dermatitis in mice associated with alterations in the gut microbiota  

作　　者：Yongjian Li Zhengping Tan Wencan Li Zongxuan Li Guiying Zhang 

机构地区：[1]Department of Dermatology,the Second Affiliated Hospital of South China University,Hengyang 421001,China [2]Department of Medical Oncology,Huxiang Cancer Hospital of Traditional Chinese Medicine,Changsha 410205,China [3]Department of Dermatology,the Second Xiangya Hospital,Central South University,Changsha 410011,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第3期345-355,共11页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grant from the Natural Science Foundation of Changsha(No.kq2202410).

摘　　要：Psoriasis is accepted as a chronic,inflammatory,immune-mediated skin disease triggered by complex environmental and genetic factors.For a long time,disease recurrence,drug rejection,and high treatment costs have remained enormous challenges and burdens to patients and clinicians.Natural products with effective immunomodulatory and anti-inflammatory activities from medicinal plants have the potential to combat psoriasis and complications.Herein,an imiquimod(IMQ)-induced psoriasis-like dermatitis model is established in mice.The model mice are treated with 1%rutaecarpine(RUT)(external use)or the oral administration of RUT at different concentrations.Furthermore,high-throughput 16S rRNA gene sequencing is applied to analyze the changes in the diversity and composition of the gut microbiota.Based on the observation of mouse dorsal skin changes,RUT can protect against inflammation to improve psoriasis-like skin damage in mice.Additionally,RUT could suppress the expression levels of proinflammatory cytokines(IL-23,IL-17A,IL-22,IL-6,and IFN-α)within skin tissue samples.Concerning gut microbiota,we find obvious variations within the composition of gut microflora between IMQinduced psoriasis mice and RUT-treated psoriasis mice.RUT effectively mediates the recovery of gut microbiota in mice induced by IMQ application.Psoriasis is linked to the production of several inflammatory cytokines and gut microbiome alterations.This research shows that RUT might restore gut microbiota homeostasis,reduce inflammatory cytokine production,and ameliorate psoriasis symptoms.In conclusion,the gut microbiota might be a therapeutic target or biomarker for psoriasis that aids in clinical diagnosis and therapy.

关 键 词：PSORIASIS rutaecarpine(RUT) inflammatory factor gut microbiota 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]