植物提取物合成银纳米粒子在龋齿治疗中应用的研究进展  

Research progress on the application of silver nanoparticles synthesized from plant extracts in the treatment of dental caries

作　　者：焦璐 王跃武 JIAO Lu;WANG Yuewu(Department of Laboratory,Bayannur Hospital,Inner Mongolia Autonomous Region,Bayannur015000,China;School of Pharmacy,Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Hohhot010110,China)

机构地区：[1]内蒙古自治区巴彦淖尔市医院检验科,内蒙古巴彦淖尔015000 [2]内蒙古医科大学药学院,内蒙古呼和浩特010110

出　　处：《中国当代医药》2024年第11期195-198,共4页China Modern Medicine

摘　　要：口腔疾病如龋齿是世界上最常见的非传染性疾病。如果不及时治疗,会发展为系统性疾病。龋齿的预防传统上依赖于口腔卫生和饮食控制,以及其他预防措施。在无机纳米材料中,银纳米粒子(AgNPs)由于其独特的物理化学性质和较强的抗菌活性,在牙科治疗中应用前景十分广阔。因此,AgNPs可能为治疗和预防牙齿感染提供新的策略。然而,人们对纳米材料的化学合成存在很多弊端,如有毒还原剂的使用。这也激发了研究者开发使用天然产物作为还原剂的绿色合成路线。与化学合成的AgNPs相比,生物源AgNPs具有良好的生物相容性。因此,采用植物合成的AgNPs具有抗菌、防污和再矿化的作用,是用于治疗龋齿和口腔疾病有前景的药物。Oral diseases such as dental caries are the most common non-communicable diseases in the world.These diseases can progress to systematic diseases when left untreated.Caries prevention has traditionally relied on oral hygiene and diet control,among other preventive measures.Among inorganic nanomaterials,silver nanoparticles(AgNPs)have shown promising outcomes in dental therapy,due to their unique physicochemical properties and enhanced anti-bacterial activities.Sealing materials are important factors that affect the anticarious effect.The most common use of sealing materials includes resin-based sealants and glass ionomer sealants.As such,AgNPs may provide newer strategies for treatment and prevention of dental infections.However,many drawbacks around the chemical synthesis of nanomaterials,which are not limited to the use of toxic reducing agents,have been raised.This has inspired researchers to develop the green synthesis route,which uses natural products as reducing agents.The biogenic AgNPs were reported to be biocompatible and environmentally friendly when compared to the chemically-synthesized AgNPs.As such,plant-synthesized AgNPs can be used as antimicrobial,antifouling,and remineralizing agents for the treatment of dental caries and oral diseases.

关 键 词：龋齿 银纳米粒子 绿色合成 抗菌剂 植物化学物质 

分 类 号：R781.1[医药卫生—口腔医学]