雷珠单抗玻璃体联合治疗眼底视网膜静脉阻塞所致的新生血管性青光眼的疗效探讨  

Efficacy of Leizumab Vitreous Combined Treatment of Neovascular Glau⁃coma Caused by Fundus Retinal Vein Obstruction

作　　者：柯发东 KE Fadong(Department of Ophthalmology,Changzhou Seventh People's Hospital,Changzhou,Jiangsu Province,213011 China)

机构地区：[1]常州市第七人民医院眼科,江苏常州213011

出　　处：《中外医疗》2024年第6期94-97,共4页China & Foreign Medical Treatment

摘　　要：目的探究雷珠单抗玻璃体在眼底视网膜静脉阻塞所致的新生血管性青光眼中的治疗意义。方法单纯随机选取于2019年6月—2022年12月常州市第七人民医院收治的80例新生血管性青光眼患者,通过随机数表法分成两组。对照组(40例)患者接受复合式小梁切除术治疗;观察组40例患者接受雷珠单抗玻璃体治疗+复合式小梁切除术治疗。对比治疗结果和眼压、视力、不良反应发生率。结果观察组治疗有效率为97.50%,高于对照组的82.50%,差异有统计学意义(χ^(2)=5.000,P<0.05);治疗前,两组眼压和视力比较,差异无统计学意义(P均>0.05);治疗后,观察组指标优于对照组,差异有统计学意义(P均<0.05);观察组不良反应发生率更低,差异有统计学意义(P<0.05)。结论雷珠单抗玻璃体结合复合式小梁切除术疗效更为确切,眼底视网膜静脉阻塞所致的新生血管性青光眼患者眼压和视力在治疗后均改善,且不良反应发生率更低。Objective To explore the therapeutic significance of leizumab vitreous in the treatment of neovascular glaucoma caused by fundus retinal vein obstruction.Methods A total of 80 patients with neovascular glaucoma who came to Changzhou Seventh People's Hospital from June 2019 to December 2022 were randomly selected and they were divided into two groups according to random number table method.40 patients in the control group received com-bined trabeculectomy,and 40 patients in the observation group received leizumab vitreous therapy plus combined trab-eculectomy.The treatment results,intraocular pressure(IOP),visual acuity and the incidence of adverse reactions were compared.Results The effective rate of observation group was 97.50%,which was higher than that of control group(82.50%),and the difference was statistically significant(χ^(2)=5.000,P<0.05).Before treatment,there was no sta-tistically significant difference in IOP and visual acuity between two groups(both P>0.05).After treatment,the index of observation group were better than those of the control group,and the differences were statistically significant(both P<0.05).The incidence of adverse reactions was lower in the observation group than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Leizumab vitreous combined trabeculectomy has a more accurate effect,and the intraocular pressure and visual acuity of the patients with neovascular glaucoma caused by fundus retinal vein occlusion are improved after treatment,and the incidence of adverse reactions are lower.

关 键 词：眼底视网膜静脉阻塞 新生血管性青光眼 雷珠单抗 复合式小梁切除术 

分 类 号：R775[医药卫生—眼科]