碘125粒子和调强适形放疗治疗淋巴结继发恶性肿瘤对比  

Comparison of Iodine-125 Particles and Intensity Modulated Conformal Radiotherapy in the Treatment of Secondary Malignant Tumors of Lymph Nodes

作　　者：杜珏欣 DU Juexin(Department of Internal Medicine,Yixing Cancer Hospital,Yixing,Jiangsu Province,214200 China)

机构地区：[1]宜兴市肿瘤医院内科,江苏宜兴214200

出　　处：《中外医疗》2024年第6期110-113,共4页China & Foreign Medical Treatment

摘　　要：目的探讨碘125粒子和调强适形放疗在治疗淋巴结继发恶性肿瘤中的效果。方法随机选取于2020年3月—2022年9月宜兴市肿瘤医院收治的60例淋巴结继发恶性肿瘤患者为研究对象,按照随机数表法分成对照组和观察组,各30例。对照组患者接受调强适形放疗治疗,观察组患者接受碘125粒子治疗。对比两组治疗结果,肿瘤标志物以及免疫功能水平。结果观察组的客观缓解率为86.67%,疾病控制率为96.67%,均高于对照组的63.33%、76.67%,差异有统计学意义(χ^(2)=4.356、5.192,P均<0.05)。治疗前,两组肿瘤标志物水平比较,差异无统计学意义(P>0.05);治疗后,观察组肿瘤标志物水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者免疫功能水平比较,差异无统计学意义(P>0.05);治疗后,观察组免疫功能水平高于对照组,差异有统计学意义(P<0.05)。结论碘125粒子在治疗淋巴结继发恶性肿瘤患者中具有更好的结果,在改善患者肿瘤标志物和免疫功能中有促进作用。Objective To investigate the effect of Iodine-125 particle and intensity modulated conformal radiotherapy in the treatment of secondary malignant tumors of lymph nodes.Methods 60 patients with secondary malignant tumor of lymph nodes admitted to Yixing Cancer Hospital from March 2020 to September 2022 were randomly selected as the research subjects.They were randomly divided into a control group and an observation group using a random num-ber table method,with 30 cases in each group.The control group received intensity-modulated radiotherapy,and the observation group received iodine-125 particles.Treatment outcomes,the levels of tumor markers and immune func-tion were compared between the two groups.Results The objective remission rate and disease control rate of the obser-vation group were 86.67%and 96.67%,which were higher than the control group's 63.33%and 76.67%,and the dif-ferences were statistically significant(χ^(2)=4.356,5.192,both P<0.05).Before treatment,there were no statistically sig-nificant differences in the levels of tumor markers between the two groups(P>0.05).After treatment,the levels of tu-mor markers in the observation group were lower than that in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in immune function levels between the two groups of patients before treatment(P>0.05).After treatment,the levels of immune function of the observation group were higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Io-dine-125 has a better results in the treatment of patients with secondary lymph node malignancies,and has a promot-ing effect in improving tumor markers and immune function of patients.

关 键 词：淋巴结继发恶性肿瘤 碘125粒子 调强适形放疗 治疗结果 

分 类 号：R738[医药卫生—肿瘤]