不同海拔地区不同年龄、性别健康成人睡眠监测指标差异性及临床意义研究  

Variations and Clinical Significance of Sleep Monitoring Indicators among Healthy Adults of Different Ages and Genders in Various Altitudes

作　　者：杨凌麟[1] 陈宇洁[1] 王怡 李勇[1] YANG Linglin;CHEN Yujie;WANG Yi;LI Yong(Pulmonary and Critical Care Medicine,the Fourth People's Hospital of Sichuan Province,Chengdu 610000,China;Sleep Center,Yunnan People's Hospital,Kunming 650000,China)

机构地区：[1]四川省第四人民医院呼吸与危重症医学科,四川省成都市610000 [2]云南省人民医院睡眠中心,云南省昆明市650000

出　　处：《中国全科医学》2024年第24期2961-2968,共8页Chinese General Practice

基　　金：四川省科技厅四川省国际科技创新合作/港澳台科技创新合作项目(2019YFH0168)。

摘　　要：背景睡眠问题是高海拔环境最常见的健康问题。目前对健康人群睡眠结构的研究仅限于同一海拔高度,且研究受试者数量较少,研究的可靠性尚未得到充分认证。目的对不同海拔地区,不同年龄、不同性别健康成人睡眠监测指标差异性进行研究分析,探讨海拔高度和年龄、性别的交互作用对睡眠监测指标的影响。方法选取2020年1月—2022年9月四川省成都市平原地区和云南省昆明市高原地区招募的健康志愿者作为研究对象。收集志愿者的性别、身高、体质量、匹兹堡睡眠质量指数(PSQI)、Epworth睡眠质量指数(ESS)。记录总睡眠时间(TST)、睡眠效率、睡眠参数[非快速眼动睡眠1期占总睡眠时间的百分比(N1%)、非快速眼动睡眠2期占总睡眠时间的百分比(N2%)、非快速眼动睡眠3期占总睡眠时间的百分比(N3%)、快速眼动睡眠期占总睡眠时间的百分比(REM%)]。将年龄作为二分类变量(20~39岁及40~60岁),采用双因素方差分析探究年龄、性别与海拔对各睡眠参数的影响。结果低海拔地区共招募91人,其中男48人、女43人;高海拔地区共招募90人,其中男46人、女44人。女性群体中,高海拔地区TST高于低海拔地区(P<0.05);男性群体与女性群体中,高海拔地区N1%高于低海拔地区,N2%低于低海拔地区(P<0.05);高海拔地区女性N3%高于男性(P<0.05);男性群体中,高海拔地区REM%高于低海拔地区(P<0.05)。高海拔地区20~39岁群体TST高于40~60岁群体(P<0.05);40~60岁群体低海拔地区睡眠效率高于高海拔地区,高海拔地区20~39岁群体睡眠效率高于40~60岁群体(P<0.05);20~39岁群体与40~60岁群体中,高海拔地区N1%均高于低海拔地区(P<0.05);低海拔地区20~39岁群体N1%高于40~60岁群体,高海拔地区20~39岁群体N1%低于40~60岁群体(P<0.05);20~39岁群体与40~60岁群体中,低海拔地区N2%均高于高海拔地区(P<0.05);高海拔地区40~60岁人群N2%高于20~39岁人群(PBackground Sleep disturbances are the most common health issues in high-altitude environments.Current research on the sleep architecture of healthy populations is limited to the same altitude and involves a small number of subjects,lacking sufficient reliability.Objective This study aims to analyze the differences in sleep monitoring indicators among healthy adults of different ages and genders across various altitudes,exploring the impact of altitude,age,and gender interactions on these indicators.Methods Healthy volunteers recruited from the plains of Chengdu,Sichuan Province,and the plateau area of Kunming,Yunnan Province,from January 2020 to September 2022 were selected as study subjects.Volunteers'gender,height,body mass,Pittsburgh Sleep Quality Index(PSQI),and Epworth Sleepiness Scale(ESS)were collected.Total sleep time(TST),sleep efficiency,and sleep parameters[percentage of stage N1(N1%),stage N2(N2%),stage N3(N3%)of non-rapid eye movement(NREM)sleep,and rapid eye movement(REM)sleep in total sleep time]were recorded.Age was categorized into two groups(20-39 and 40-60 years)for a two-way ANOVA to explore the effects of age,gender,and altitude on sleep parameters.Result A total of 91 people were recruited in low-altitude areas,including 48 men and 43 women.A total of 90 people were recruited for the high-altitude area,including 46 men and 44 women.In females,TST was higher in high-altitude areas compared to low-altitude areas(P<0.05).In both males and females,N1%was higher and N2%was lower in high-altitude areas(P<0.05).N3%was higher in females than in males in high-altitude areas(P<0.05).In males,REM%was higher in high-altitude areas(P<0.05).TST was higher in the 20-39 age group than in the 40-60 age group in high-altitude areas(P<0.05).Sleep efficiency was higher in the 40-60 age group in low-altitude areas compared to high-altitude areas,with the 20-39 age group showing higher sleep efficiency in high-altitude areas(P<0.05).In both age groups,N1%was higher in high-altitude areas(P<0.05).In low-altitude a

关 键 词：睡眠异常 高海拔 睡眠监测 成年人 

分 类 号：R749.79[医药卫生—神经病学与精神病学]