上皮性卵巢癌组织中MSLN、ERBB2表达及其临床意义  

Expressions and Clinical Significance of MSLN and ERBB2 in Epithelial Ovarian Cancer Tissues

作　　者：刘星辰 蔡俊 刘忠强 LIU Xingchen;CAI Jun;LIU Zhongqiang(Xinyang Central Hospital,Xinyang,464000)

机构地区：[1]河南省信阳市中心医院,464000

出　　处：《实用癌症杂志》2024年第5期738-741,共4页The Practical Journal of Cancer

摘　　要：目的分析上皮性卵巢癌组织间皮素(MSLN)、络氨酸激酶受体-2(ERBB2)表达及其临床意义。方法回顾性分析92例上皮性卵巢癌患者的临床资料,根据其1年随访结果将其分为预后不良组(n=37)和预后良好组(n=55),对比两组患者肿瘤组织MSLN mRNA、ERBB2 mRNA水平差异,并评估预测效能,比较不同临床病理特征的上皮性卵巢癌组织MSLN mRNA、ERBB2 mRNA的表达水平差异,再通过COX回归模型分析上述指标与患者无进展生存期的关系。结果预后良好组相较于预后不良组,MSLN mRNA、ERBB2 mRNA表达水平低,差异有统计学意义(P<0.05),MSLN mRNA、ERBB2 mRNA表达水平可用于预测预后,对应的cut-off值分别为1.42、2.47,MSLN mRNA、ERBB2 mRNA低表达的患者无进展生存期更长(P<0.05),MSLN mRNA、ERBB2 mRNA表达水平与淋巴结转移、肿瘤分化情况有明显相关性(P<0.05)。结论上皮性卵巢癌组织中MSLN、ERBB2表达与患者预后及临床病理特征均密切相关,可作为早期诊治策略制定的参考依据。Objective To analyze the expressions and clinical significance of mesothelin(MSLN)and tyrosine kinase receptor-2(ERBB2)in epithelial ovarian cancer tissues.Methods The clinical data of 92 patients with epithelial ovarian cancer were retrospectively analyzed.According to 1-year follow-up results,the patients were divided into poor prognosis group(n=37)and good prognosis group(n=55).The differences in MSLN mRNA and ERBB2 mRNA in tumor tissues were compared between the 2 groups.The predictive efficiency was assessed,and the differences in the expressions of MSLN mRNA and ERBB2 mRNA in epithelial ovarian cancer tissues with different clinicopathological characteristics were compared.COX regression model was applied to analyze the relationship between the above indicators and progression-free survival time of patients.Results Compared with poor prognosis group,the expression levels of MSLN mRNA and ERBB2 mRNA in good prognosis group were lower(P<0.05).The expression levels of MSLN mRNA and ERBB2 mRNA could be used to predict the prognosis,and the corresponding cut-off values were 1.42 and 2.47 respectively,and the progression-free survival time was longer among patients with low expressions of MSLN mRNA and ERBB2 mRNA(P<0.05).The expression levels of MSLN mRNA and ERBB2 mRNA were significantly correlated with lymph node metastasis and tumor differentiation(P<0.05).Conclusion The expressions of MSLN and ERBB2 in epithelial ovarian cancer tissues are closely related to the prognosis and clinicopathological characteristics of patients,and they can be used as reference basis for the formulation of early diagnosis and treatment strategies.

关 键 词：上皮性卵巢癌 MSLN ERBB2 

分 类 号：R737.31[医药卫生—肿瘤]