Ⅱ型子宫内膜癌患者癌组织中IMP3、PTEN表达及其临床意义  

Expressions and Clinical Significance of IMP3 and PTEN in Cancer Tissues of Patients with Type Ⅱ Endometrial Carcinoma

作　　者：李颖 马媛 李凯丽 LI Ying;MA Yuan;LI Kaili(Anyang Tumor Hospital,The Fourth Affiliated Hospital of Henan University of Science and Technology,Anyang,455000)

机构地区：[1]河南科技大学第四附属医院,安阳市肿瘤医院,455000

出　　处：《实用癌症杂志》2024年第5期753-756,共4页The Practical Journal of Cancer

摘　　要：目的分析Ⅱ型子宫内膜癌(EC)患者癌组织中胰岛素样生长因子Ⅱ信使RNA结合蛋白3(IMP3)和磷酸酶与张力蛋白同源物(PTEN)的表达情况,并探讨其临床意义。方法收集60例Ⅱ型EC患者手术切除的癌组织及20例对应癌旁组织的存档石蜡标本,采用免疫组织化学法(IHC)检测标本中IMP3、PTEN蛋白表达情况;分析IMP3、PTEN蛋白表达与EC患者临床病理特征及预后的关系。结果EC患者癌组织中IMP3阳性表达率高于癌旁组织,PTEN阳性表达率低于癌旁组织,差异均有统计学意义(P<0.05)。EC患者癌组织IMP3阳性表达率与肌层浸润深度、FIGO分期及淋巴结转移有关(P<0.05),即肌层浸润深度越深、FIGO分期越晚、合并淋巴结转移者IMP3阳性表达率越高。PTEN阳性表达率与FIGO分期、淋巴结转移有关(P<0.05),即FIGO分期越晚、合并淋巴结转移者PTEN阳性表达率越低。Spearman相关性分析结果显示,EC患者癌组织中IMP3和PTEN蛋白表达无显著相关性(P>0.05)。IMP3阳性组整体生存情况差于IMP3阴性组,PTEN阳性组整体生存情况优于PTEN阴性组(P<0.05)。结论Ⅱ型EC患者癌组织中IMP3表达上调,而PTEN表达下调,二者表达异常可能参与了Ⅱ型EC的发生与发展,且IMP3阳性表达、PTEN阴性表达与Ⅱ型EC患者不良预后相关。Objective To analyze the expressions of insulin 1ike growth factorⅡmRNA binding protein 3(IMP3)and phosphatase and tensin homolog(PTEN)in cancer tissues of patients with type II endometrial carcinoma(EC),and to explore their clinical significance.Methods The archived paraffin specimens of cancer tissues from 60 patients with type ⅡEC and para-carcinoma tissues from 20 patients were collected.The expressions of IMP3 and PTEN proteins were detected by immunohistochemistry(IHC),and their relationship with clinicopathological characteristics and prognosis of EC patients was analyzed.Results The positive expression rate of IMP3 in cancer tissues was higher than that in para-carcinoma tissues,while positive expression rate of PTEN was lower than that in para-carcinoma tissues(P<0.05).The positive expression rate of IMP3 was correlated with depth of muscular infiltration,FIGO staging and lymph node metastasis(P<0.05).The positive expression rate of IMP3 was higher in patients with deep muscular infiltration,late FIGO staging and lymph node metastasis.The positive expression rate of PTEN was correlated with FIGO staging and lymph node metastasis(P<0.05).The positive expression rate of PTEN was lower in patients with late FIGO staging and lymph node metastasis.The results of Spearman correlation analysis showed that there was no significant correlation between IMP3 and PTEN(P>0.05).The overall survival in IMP3 positive group was worse than that in IMP3 negative group,while overall survival in PTEN positive group was better than that in PTEN negative group(P<0.05).Conclusion The expression of IMP3 is up-regulated,while expression of PTEN is down-regulated in cancer tissues of patients with type Ⅱ EC.The abnormal expressions of the 2 indexes may be involved in the occurrence and development of type Ⅱ EC.The positive expression of IMP3 and negative expression of PTEN are correlated with poor prognosis of patients with type Ⅱ EC.

关 键 词：Ⅱ型子宫内膜癌 胰岛素样生长因子Ⅱ信使RNA结合蛋白3 磷酸酶与张力蛋白同源物 预后 

分 类 号：R737.33[医药卫生—肿瘤]