VEGF、P53表达与食管癌淋巴结转移及其预后的相关性分析  

Correlation Analysis of VEGF and P53 Expression with Lymph Node Metastasis and Prognosis in Esophageal Cancer

作　　者：陈小霞[1] 丁子睿 贺垒 杨蕾[1] 板利娟 朱文娟 CHEN Xiaoxia;DING Zirui;HE Lei(The First People's Hospital of Xinxiang,Xinxiang,453000)

机构地区：[1]河南省新乡市第一人民医院,453000 [2]新乡医学院,453003

出　　处：《实用癌症杂志》2024年第5期774-777,共4页The Practical Journal of Cancer

摘　　要：目的分析血管内皮生长因子(VEGF)、P53表达与食管癌淋巴结转移与预后的关系。方法选取120例食管癌患者,采集其癌组织(观察组)与癌旁正常组织(对照组)标本,应用免疫组织化学法测定两组VEGF、P53表达差异;并收集患者资料,分析VEGF、P53阳性表达与食管癌临床病理特征的关系;另外随访3年,分析VEGF、P53阳性表达与食管癌患者预后的关系。结果观察组VEGF阳性率为69.17%(83/120)、P53阳性率为75.00%(90/120),均高于对照组的33.33%(40/120)、31.67%(38/120),差异有统计学意义(P<0.05);VEGF、P53阳性表达与淋巴结转移、TNM分期、分化程度、肿瘤最大径相关(P<0.05);VEGF、P53阳性表达患者的生存率低于阴性表达患者,差异有统计学意义(P<0.05)。结论VEGF、P53在食管癌组织内呈高表达,表达水平与患者的淋巴结转移、TNM分期、分化程度、肿瘤最大径等临床病理特征相关,且阳性表达患者预后更差。Objective To analyze the relationship between the expression of vascular endothelial growth factor(VEGF)and P53,and lymph node metastasis,and prognosis in esophageal cancer.Methods 120 patients with esophageal cancer were selected,and specimens of their cancer tissue(observation group)and adjacent normal tissue(control group)were collected.The expression differences of VEGF and P53 between the 2 groups were measured using immunohistochemistry;Collect patient data and analyze the relationship between the positive expression of VEGF and P53 and the clinical and pathological characteristics of esophageal cancer;In addition,a 3-year follow-up was conducted to analyze the relationship between the positive expression of VEGF and P53 and the prognosis of esophageal cancer patients.Results The positive rates of VEGF and P53 in the observation group were 69.17%(83/120)and 75.00%(90/120),respectively,which were higher than 33.33%(40/120)and 31.67%(38/120)in the control group,with statistically significant differences(P<0.05);The positive expression of VEGF and P53 was correlated with lymph node metastasis,TNM staging,differentiation degree,and maximum tumor diameter(P<0.05);The survival rate of patients with positive expression of VEGF and P53 was lower than that of patients with negative expression,and the difference was statistically significant(P<0.05).Conclusion VEGF and P53 are highly expressed in esophageal cancer tissue,and their expression levels are correlated with clinical and pathological features such as lymph node metastasis,TNM staging,differentiation degree,and maximum tumor diameter.Positive expression patients have a poorer prognosis.

关 键 词：食管癌 淋巴结转移 血管内皮生长因子 预后 

分 类 号：R735.1[医药卫生—肿瘤]