胃癌患者术前红细胞分布宽度与白蛋白比值变化及其临床意义  

Changes of Red Cell Volume Distribution Width/albumin Ratio in Patients with Gastric Cancer Before Operation and Its Clinical Significance

作　　者：刘大宁[1] 刘湛[1] LIU Daning;LIU Zhan(Puyang People's Hospital,Puyang,457000)

机构地区：[1]河南省濮阳市人民医院,457000

出　　处：《实用癌症杂志》2024年第5期785-788,792,共5页The Practical Journal of Cancer

基　　金：河南省科技攻关计划项目(编号:172102210025)。

摘　　要：目的探讨胃癌患者术前红细胞分布宽度与白蛋白比值(RDW/Alb)变化及其临床意义。方法回顾性收集53例预后良好的胃癌患者的临床资料纳入预后良好组,收集同期53例预后不良的胃癌患者的临床资料纳入预后不良组。由研究者查阅入选者的基线资料并做详细统计,观察2组患者术前RDW/Alb表达情况,分析术前RDW/Alb与胃癌患者腹腔镜根治术治疗预后的关系,并绘制受试者工作特征(ROC)曲线分析术前RDW/Alb对胃癌患者腹腔镜胃癌根治术治疗预后的预测价值。结果预后不良组TNM分期为Ⅲa期占比以及术前RDW、RDW/Alb、癌胚抗原(CEA)均高于预后良好组,术前Alb低于预后良好组,差异有统计学意义(P<0.05);2组患者年龄、性别、体重指数、肿瘤位置、手术时间、术中出血量对比,差异无统计学意义(P>0.05)。经COX生存回归分析,结果显示,TNM分期为Ⅲa期、术前RDW、RDW/Alb及CEA高表达为胃癌患者腹腔镜胃癌根治术治疗预后的危险因子(HR>1,P<0.05);术前Alb高表达为其保护因子(HR<1,P<0.05)。绘制ROC曲线,结果显示,术前RDW、Alb、RDW/Alb预测胃癌患者腹腔镜胃癌根治术治疗预后的价值的AUC均>0.7,具有一定的预测价值,其中RDW/Alb预测价值最高。结论术前RDW/Alb与胃癌患者腹腔镜胃癌根治术治疗预后有关,可作为胃癌患者预后的预测指标。Objective To investigate the changes of red cell volume distribution width and albumin ratio(RDW/Alb)in patients with gastric cancer before operation and its clinical significance.Methods Retrospective analysis was conducted to collect the clinical data of 53 patients with gastric cancer with good prognosis and included in the good prognosis group.In addition,the clinical data of 53 patients with gastric cancer with poor prognosis were collected and included in the poor prognosis group.The baseline data of the selected patients were reviewed by the researchers and detailed statistics were made.The expression of preoperative RDW/Alb in the 2 groups was observed.The relationship between preoperative RDW/Alb and the prognosis of laparoscopic radical gastrectomy in patients with gastric cancer was analyzed.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of preoperative RDW/Alb ratio for the prognosis of laparoscopic radical gastrectomy in patients with gastric cancer.Results The proportion of TNM stage Ⅲa in the poor prognosis group,as well as the preoperative RDW,RDW/Alb and carcinoembryonic antigen(CEA)were higher than those in the good prognosis group,and the preoperative Alb was lower than that in the good prognosis group,the difference was statistically significant(P<0.05).There was no statistical significant difference between the 2 groups in age,sex,body mass index,tumor location,operation time and intraoperative bleeding(P>0.05).The results of COX survival regression analysis showed that TNM stage Ⅲa,preoperative RDW,RDW/Alb ratio and CEA high expression were risk factors for the prognosis of patients with gastric cancer after laparoscopic radical gastrectomy(HR>1,P<0.05).The high expression of Alb before operation was its protective factor(HR<1,P<0.05).The ROC curve was drawn,and the results showed that the AUC of preoperative RDW,Alb,and RDW/Alb ratios in predicting the prognosis of patients undergoing laparoscopic radical gastrectomy for gastric cancer was more

关 键 词：胃癌 红细胞分布宽度 白蛋白 预后 

分 类 号：R735.2[医药卫生—肿瘤]