多发性骨髓瘤合并骨髓纤维化患者的临床特征及预后研究  

Clinical Characteristics and Prognosis of Patients with Multiple Myeloma and Myelofibrosis

作　　者：李娅婷 LI Yating(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2024年第5期849-851,855,共4页The Practical Journal of Cancer

摘　　要：目的探讨多发性骨髓瘤(MM)合并骨髓纤维化患者的临床特征及预后。方法回顾性分析83例MM患者临床资料,将50例单纯MM患者设为对照组,将33例合并骨髓纤维化的MM患者设为观察组。所有患者采用以硼替佐米为基础的化疗方案,并收集疾病分期、分型及遗传学特点相关资料,分析2组疗效及疾病分期、分型、遗传学特点间差异,并随访3年,比较2组预后间差异。结果观察组有效率低于对照组,差异有统计学意义(P<0.05)。2组DS分期、ISS分期、MM分型相比,差异无统计学意义(P>0.05);观察组FISH、1q21扩增、D13S319缺失、IGH断裂阳性率高于对照组,差异有统计学意义(P<0.05)。观察组生存率低于对照组,差异有统计学意义(P<0.05)。结论MM合并骨髓纤维化患者临床疗效偏差,易出现FISH、1q21扩增、D13S319缺失、IGH断裂阳性情况,且整体预后欠佳。Objective To explore the clinical characteristics and prognosis of patients with multiple myeloma(MM)and myelofibrosis.Methods A retrospective analysis was conducted on the clinical data of 83 MM patients,with 50 simple MM patients as the control group and 33 MM patients with bone marrow fibrosis as the observation group.All patients underwent a chemotherapy regimen based on bortezomib,and relevant data on disease staging,typing,and genetic characteristics were collected.The differences in efficacy,disease staging,typing,and genetic characteristics between the 2 groups were analyzed,and a 3-year follow-up was conducted to compare the differences in prognosis between the 2 groups.Results The effective rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the 2 groups in DS staging,ISS staging,and MM typing(P>0.05);The positive rates of FISH,1q21 amplification,D13S319 deletion,and IGH cleavage in the observation group were higher than those in the control group,with statistical significance(P<0.05).The survival rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of patients with MM combined with bone marrow fibrosis is biased,prone to FISH,1q21 amplification,D13S319 deletion,and IGH breakage positivity,and the overall prognosis is poor.

关 键 词：多发性骨髓瘤 骨髓纤维化 临床特征 预后 

分 类 号：R733.3[医药卫生—肿瘤]