穴位注射外泌体给药载体可行性的思考与探究  

Feasibility of acupoint injection of exosome drug delivery carriers:Consideration and ex⁃ploration

作　　者：肖展 梁霄 孙鑫 文武龙 张炜烨 赵玉强 杨婧[2] 王锐[1] XIAO Zhan;LIANG Xiao;SUN Xin;WEN Wu-long;ZHANG Wei-ye;ZHAO Yu-qiang;YANG Jing;WANG Rui(College of Pharmacy of Heilongjiang University of Traditional Chinese Medicine,Harbin Heilongjiang,150040,China;Basic Medical College of Heilongjiang University of Traditional Chinese Medicine,Harbin Heilongjiang,150040,China)

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040 [2]黑龙江中医药大学基础医学院,黑龙江哈尔滨150040

出　　处：《时珍国医国药》2024年第1期149-153,共5页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(82074271,81603418)。

摘　　要：外泌体作为胞间物质交流和信息传递的重要载体,近年来通过结构修饰和装载药物已在疾病治疗中得到广泛的应用,成为了药物递送领域的研究热点。穴位注射是能够发挥针刺效应和药物性能的中西医结合疗法,具有药效强、作用快、安全性高等特点,具有巨大的开发潜力。文章基于目前穴位注射外泌体的应用现状和理论基础,提出了需解决的问题和未来展望。Exosomes,as important carriers of intercellular material exchange and information transmission,have been widely used in disease treatment through structural modification and drug loading in recent years,and have become a research hotspot in the field of drug delivery.Acupoint injection is a combination of traditional Chinese and western medicine which can give full play to acupuncture effects and drug properties.It has the characteristics of strong efficacy,fast action and high safety,and has great potential for development.Based on the current application status and theoretical basis of acupoint injection of exosomes,the problems to be solved and future prospects were put forward.

关 键 词：外泌体 给药载体 给药途径 穴位注射 针刺效应 

分 类 号：R245.95[医药卫生—针灸推拿学]