MEN1基因突变和menin蛋白在乳腺癌中的作用  

Role of MEN1 gene mutation and menin protein in breast cancer

作　　者：程璐 任艳 宋爱琳[1,2] CHEN Lu;REN Yan;SONG Ailin(The Second Clinical Medical College of Lanzhou University,Lanzhou 730000,China;General Surgery Department of Lanzhou University Second Hospital,Lanzhou 730030 China)

机构地区：[1]兰州大学第二临床医学院,兰州730000 [2]兰州大学第二医院普外科,兰州730030

出　　处：《生命的化学》2024年第3期505-513,共9页Chemistry of Life

基　　金：甘肃省自然科学基金项目(20JR5RA342,21JR11RA109)。

摘　　要：乳腺癌已成为全球女性患者最大的癌症负担。在中国,近10%的女性乳腺癌患者发病与遗传相关,受多个易感基因调控。乳腺癌患者存在多发性内分泌肿瘤1型(multiple endocrine neoplasia type 1,MEN1)基因显著突变,MEN1突变女性患乳腺癌风险显著增加,发病年龄提前。关于MEN1影响乳腺癌发病与进展的系统研究仍然有限。因此,本文将基于MEN1基因和MEN1编码的menin蛋白的结构、功能作一概述,以探讨MEN1与menin在乳腺癌发生发展及内分泌治疗中的作用机制,并介绍了基于menin的乳腺癌潜在治疗靶点,旨在为乳腺癌的早期筛查及个体化防治提供理论支持和科学指导。Breast cancer has become the largest cancer burden among women worldwide.In China,nearly 10%of female breast cancer patients are genetically related and regulated by multiple susceptibility genes.Breast cancer patients have significant mutations in the multiple endocrine neoplasia type 1(MEN1)gene,and women with MEN1 mutations have a significantly increased risk of breast cancer and an earlier age of onset.Systematic studies on the effects of MEN1 on the onset and progression of breast cancer remain limited.Therefore,the structure and function of MEN1 gene and MEN1-encoded menin protein are summarized in this paper,so as to explore the mechanism of MEN1 and menin in the occurrence and development of breast cancer and endocrine therapy,and introduce the potential therapeutic targets of breast cancer based on menin.The aim is to provide theoretical support and scientific guidance for the early screening and individual prevention of breast cancer.

关 键 词：MEN1基因 MENIN蛋白 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]