肠道Lachnoclostridium菌属丰度与首次发病精神分裂症认知损害的关联研究  

Research on the correlation between the abundance of Lachnoclostridium genus in gut microbiome and cognitive impairment in first-episode schizophrenia

作　　者：赵心怡 袁秀霞[1] 孙尧 庞礼娟[1] 李雪[1] 黑钢瑞[1] 宋学勤[1] Zhao Xinyi;Yuan Xiuxia;Sun Yao;Pang Lijuan;Li Xue;Hei Gangrui;Song Xueqin(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院,郑州450000

出　　处：《中华精神科杂志》2024年第4期221-228,共8页Chinese Journal of Psychiatry

基　　金：国家自然科学基金(U21A20367,81971253,82201657);河南省医学科技攻关计划联合共建项目(LHGJ20220310);河南省高校科技创新团队(21IRTSTHN027);郑州大学第一附属医院科研创新团队(ZYCXTD2023015)。

摘　　要：目的探讨肠道Lachnoclostridium菌丰度和炎症指标与首次发病精神分裂症认知功能损害的关系。方法选取2020年1月至2022年12月就诊于郑州大学第一附属医院精神医学科的首次发病未用药精神分裂症患者87例(患者组)和健康对照者87名(对照组),患者组采用利培酮治疗。对所有受试者进行24周的随访,分别在基线和24周时采集静脉血和粪便样本,检测超氧化物歧化酶1(superoxide dismutase-1,SOD-1)水平和血红细胞沉降率(erythrocyte sedimentation rate,ESR)及Lachnoclostridium菌的丰度。采用阳性和阴性症状量表评估患者症状严重程度,采用认知功能成套测验评估所有受试者认知功能。2组及患者组治疗前后Lachnoclostridium菌丰度、炎症指标、认知评分的差异比较采用t检验;采用Pearson相关分析法,分析Lachnoclostridium菌丰度与炎症指标、认知评分的相关性。结果基线时,与对照组相比,患者组SOD-1水平、认知功能成套测验总分均较低(t=6.83、6.35,均P<0.001),Lachnoclostridium菌丰度较高(Z=-4.64,P<0.001)。基线时患者组SOD-1水平与社会认知评分呈正相关(r=0.30,P=0.005),ESR与信息处理速度、社会认知评分呈负相关(r=-0.23、-0.31,均P<0.050);Lachnoclostridium菌丰度与信息处理速度(r=-0.28,P=0.009)、工作记忆(r=-0.22,P=0.040)、视觉记忆(r=-0.32,P=0.003)评分呈负相关。24周时,与基线时相比,患者组SOD-1水平(t=-2.07,P=0.045)、认知功能成套测验总分(t=-3.47,P=0.001)升高,ESR(t=2.21,P=0.033)降低,Lachnoclostridium菌丰度有降低的趋势(Z=1.52,P=0.128)且与对照组比较差异无统计学意义(Z=1.68,P=0.094)。完成24周随访的39例精神分裂症患者中,基线时Lachnoclostridium菌丰度与24周时注意与警觉性评分(r=-0.39,P=0.014)、认知功能成套测验总分(r=-0.34,P=0.032)呈负相关;基线时ESR水平与信息处理速度评分、工作记忆评分、社会认知评分、认知功能成套测验总分这4个指标的24周�Objective This study aims to explore the relationship between the abundance of Lachnoclostridium genus in the gut microbiome and inflammatory markers with cognitive impairment in patients with first-episode schizophrenia.Methods A total of 87 medication-naive patients with first-episode schizophrenia(patient group)and 87 matched healthy controls(control group)who visited the Department of Psychiatry,the First Affiliated Hospital of Zhengzhou University between January 2020 and December 2022 were selected for this study.A 24-week follow-up was conducted for the patients,and all patients received treatment with risperidone.Venous blood and fecal samples were collected from the subjects at baseline and week 24 to measure the levels of superoxide dismutase-1,erythrocyte sedimentation rate,and the abundance of Lachnoclostridium.The severity of symptoms in patients with schizophrenia was assessed using the Positive and Negative Syndrome Scale,and the cognitive function of all subjects was evaluated using MATRICS Consensus Cognitive Battery tests.The differences in the abundance of Lachnoclostridium,inflammatory markers,and cognitive scores between groups were analyzed using t-tests,and the correlations between Lachnoclostridium abundance,inflammatory markers,and cognitive scores were analyzed using Pearson correlation analysis.Results(1)At baseline,compared with the control group,patients with first-episode schizophrenia had lower levels of superoxide dismutase-1(t=6.83,P<0.001)and total cognitive function test scores(t=6.35,P<0.001),and higher abundance of Lachnoclostridium(Z=-4.64,P<0.001).(2)At baseline,the levels of superoxide dismutase-1 in patients with first-episode schizophrenia were positively correlated with social cognition(r=0.30,P=0.005),while erythrocyte sedimentation rate was negatively correlated with information processing speed and social cognition(r=-0.23,-0.31,both P<0.050).The abundance of Lachnoclostridium genus was negatively correlated with speed of processing(r=-0.28,P=0.009),working memory(r=-

关 键 词：精神分裂症 超氧化物歧化酶 血沉 Lachnoclostridium 

分 类 号：R749.3[医药卫生—神经病学与精神病学]