抑郁症共病代谢综合征免疫炎症机制的研究进展  

Research progress on immune inflammatory mechanism of metabolic syndrome comorbidity of depression

作　　者：吴阳雨 张剑昭 宋小东 钟舒明[1] 贾艳滨[1] Wu Yangyu;Zhang Jianzhao;Song Xiaodong;Zhong Shuming;Jia Yanbin(Department of Psychiatry,the First Affiliated Hospital of Jinan University,Guangzhou 510630,China)

机构地区：[1]暨南大学附属第一医院精神医学科,广州510630

出　　处：《中华精神科杂志》2024年第4期245-250,共6页Chinese Journal of Psychiatry

基　　金：国家自然科学基金(82271564);广州市科技计划项目(202201020047);2022年国家重点研发计划“先进计算与新兴软件”重点专项(2022YFB4500600)。

摘　　要：抑郁症患者代谢综合征患病率显著高于健康人群,代谢紊乱被证实与抑郁症发病、不良治疗结局及疾病复发密切相关。因此,揭示两者共病机制对于抑郁症的全病程治疗具有重大意义。既往研究多关注下丘脑-垂体-肾上腺轴紊乱介导的皮质醇水平异常在其中的作用,然而这一通路如何被激活和调控仍不明确。近年来,随着研究的进一步深入,免疫系统异常诱发的系统性炎症被认为是抑郁症共病代谢综合征的深层分子机制。本综述旨在通过总结抑郁症和代谢综合征在固有免疫、适应性免疫及免疫信号通路的相似激活,为后续机制探索、药物研发和干预策略寻找提供有力的理论依据。The prevalence of metabolic syndrome(MetS)in patients with major depressive disorder(MDD)is significantly higher than that in healthy people.Metabolic disorder has been proven to be closely related to the onset of MDD,adverse treatment outcome and disease recurrence.Therefore,revealing the comorbidity mechanism of both is of great significance for treating MDD.Previous studies have focused on the role of abnormal cortisol levels mediated by hypothalamic-pituitary-adrenal axis disorder,but how this pathway is activated and regulated is still unclear.In recent years,with further research development,systemic inflammation induced by an abnormal immune system is considered the deep molecular mechanism of MetS comorbidity of MDD.This review aims to summarize the similar activation of innate immunity,adaptive immunity and immune signaling pathway between MDD and MetS and to provide a strong theoretical basis for follow-up mechanism exploration,drug research and intervention strategy search.

关 键 词：抑郁症 代谢综合征 免疫炎症 病理机制 

分 类 号：R749.4[医药卫生—神经病学与精神病学]