2023年肿瘤精准医学发展态势  

Development trend of precision oncology in 2023

作　　者：李伟[1] 杨若南 徐萍[1,2] 靳晨琦 许丽 LI Wei;YANG Ruo-Nan;XU Ping;JIN Chen-Qi;XU Li(Shanghai Information Center for Life Sciences,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,Shanghai 200031,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院上海生命科学信息中心,中国科学院上海营养与健康研究所,上海200031 [2]中国科学院大学,北京100049

出　　处：《生命科学》2024年第1期63-71,共9页Chinese Bulletin of Life Sciences

基　　金：中国科学院文献情报能力建设专项(E3290422)子课题“生命科学与健康领域科技态势分析与服务”;中国科学院科技智库研究员项目(2023-ZY01-B-032)。

摘　　要：肿瘤的高度复杂性和异质性使其治疗面临巨大挑战,而精准医学的发展为其带来新机遇,成为肿瘤医学的重要发展模式。经过几年的发展,肿瘤精准医学不断推进,相关成果持续涌现。该文在系统梳理2023年全球肿瘤精准医学的发展布局与举措,总结领域发展现状与发展趋势的基础上,展望了肿瘤精准医学领域的未来发展方向。当前,全球已建设多个肿瘤相关的大型人群队列,为肿瘤精准医学的实现提供了重要资源基础。随着精准医学理念的深入和生命组学技术的革新,基因检测、液体活检、伴随诊断等精准诊断技术以及靶向药物、免疫治疗、RNA疗法等先进治疗手段逐渐成熟,不仅推动了对肿瘤发生发展机制的深入解析,使得肿瘤精准分型取得快速突破,并逐渐用于指导临床实践;而且推动了新技术、新应用、新产品的快速突破,从而助推肿瘤精准医学的实现。Tumor heterogeneity greatly hinders effective and individualized tumor treatment.However,precision medicine creats new avenues for tumor treatment,and becomes a significant development model in medical oncology.Here we systematically analyze the current developments of precision oncology in 2023 and anticipate the future directions.Currently,numerous large-scale population cohorts focused on tumor-related research have been established worldwide and provide a crucial resource foundation for the implementation of precision oncology.The development of precision medicine and life omics technologies accelerates the rapid development of tumor molecular classification,precise diagnostic technologies such as genetic test,liquid biopsy,and companion diagnostic,along with advanced therapeutic approaches such as targeted drugs,immunotherapy,and RNA therapy.Furthermore,novel technologies,applications,and products are achieving breakthroughs,thereby facilitating the implementation of precision oncology.

关 键 词：肿瘤精准医学 人群队列 生命组学 分子分型 精准防诊治 

分 类 号：R730.5[医药卫生—肿瘤]