Phosphine-Catalyzed [4+3] Annulation Reaction of Indole Derivatives with MBH Carbonates:A Facile Access to Indole-1,2-fused 1,4-Diazepinones and Azepines  

作　　者：Yannan Zhu Haoran Jiang Yi-Ning Wang 

机构地区：[1]Faculty of Chemistry and Chemical Engineering,Yancheng Institute of Technology,Yancheng,Jiangsu,224051 China

出　　处：《Chinese Journal of Chemistry》2024年第3期271-275,共5页中国化学（英文版）

基　　金：the financial support from the funding for school-level research projects of Yancheng Institute of Technology(No.XJR2022019,XJ201719).

摘　　要：A phosphine-catalyzed [4+3] annulation between dinucleophilic indole derivatives and Morita−Baylis−Hillman (MBH) carbonates was discovered by using the N1 and N4′/C4′ nucleophilicities of the indole precursors,in which indoles act as four atom synthons. This protocol provides an efficient and facile access to indole-1,2-fused 1,4-diazepinones and azepines in good to high yields in one step,which illustrates potential synthetic utilities in drug discovery.

关 键 词：Phosphine catalysis [4+3]Annulation Indole derivatives Nitrogen heterocycles ORGANOCATALYSIS 

分 类 号：O62[理学—有机化学]