NOX2参与适应性免疫反应及其与慢性肉芽肿病伴随性自身免疫病的联系  

Effects of NOX2 in adaptive immune response and its correlation with autoimmune diseases associated with chronic granulomatous disease

作　　者：苏晓亚 洪莉[2,3] 陈同辛[1,2] SU Xiao-ya;HONG Li;CHEN Tong-xin(Department of Rheumatology and Immunology,Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Pediatric Translational Medicine Institute,Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Clinical Nutrition,Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心风湿免疫科,上海200127 [2]上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所,上海200127 [3]上海交通大学医学院附属上海儿童医学中心临床营养科,上海200127

出　　处：《现代免疫学》2024年第2期165-169,共5页Current Immunology

基　　金：国家自然科学基金(81871303)。

摘　　要：吞噬细胞还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶又称NOX2,是一种多组分酶复合物,在宿主免疫防御和免疫调节中发挥重要作用。NOX2组分功能缺陷会导致慢性肉芽肿病(chronic granulomatous disease,CGD)。NOX2缺陷引起的固有免疫反应改变是CGD感染性疾病发生的主要原因。随着对CGD发病机制的深入研究,发现NOX2缺陷能够影响T、 B细胞介导的免疫应答,进而影响CGD患者自身免疫病的发生、发展。该文将对NOX2缺陷引起的适应性免疫的改变及其与CGD患者伴随性自身免疫病的关系进行综述。Phagocyte nicotinamide adenine dinucleotide phosphate oxidase(NOX2),is a multicomponent enzyme complex that plays an important role in host immune defense and immune regulation.Functional defect of NOX2 correlates with the occurrence of chronic granulomatous disease(CGD).NOX2 deficiency may alter innate immune response which is the main cause of CGD infectious diseases.Further study on the pathogenesis of CGD finds that NOX2 deficiency may regulate T and B cell-mediated immune responses,thus affecting the occurrence and development of autoimmune diseases in CGD patients.This review discusses the changes in adaptive immunity caused by NOX2 deficiency and its relationship with concomitant autoimmune diseases in CGD patients.

关 键 词：吞噬细胞还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶 慢性肉芽肿病 适应性免疫 自身免疫病 

分 类 号：R392[医药卫生—免疫学]