三种不同支架置入辅助弹簧圈栓塞治疗颅内动脉瘤的疗效及安全性比较  

Comparison of the efficacy and safety of three different stent implantation assisted embolization for intracranial aneurysms

作　　者：卞立松 何远东[1] 齐佳伟 甄宇航 柳江[1] BIAN Li-song;HE Yuan-dong;QI Jia-wei;ZHEN Yu-hang;LIU Jiang(Department of Neurosurgery,Beijing Haidian Hospital,Beijing 100012,China)

机构地区：[1]北京市海淀医院神经外科,北京100012

出　　处：《川北医学院学报》2024年第4期457-460,共4页Journal of North Sichuan Medical College

基　　金：首都卫生发展科研专项(首发2020-2-1153)。

摘　　要：目的:比较Solitaire AB、Neuroform、Lvis/Lvis jr支架分别置入辅助弹簧圈栓塞治疗颅内动脉瘤的疗效及安全性。方法:回顾性分析接受弹簧圈栓塞治疗的103例颅内动脉瘤患者的临床资料,根据治疗方案将其分为Solitaire AB组(n=37),Neuroform组(n=34)及Lvis/Lvis jr组(n=32),比较各组患者的治疗效果及安全性。结果:各组患者支架均定位满意,且成功释放,技术成功率均为100%。术后即刻、术后6个月,Lvis/Lvis jr组Raymond分级优于Solitaire AB组和Neuroform组(P<0.05)。治疗后,各组患者血清神经生长因子(NGF)、S-100B蛋白表达水平均降低(P<0.05),且Lvis/Lvis jr组低于Solitaire AB组和Neurofor组(P<0.05)。术后6个月,各组患者屏气前动脉平均血流流速(Vm)、屏气后Vm、屏气指数(BHI)及改良Rankin量表(mRs)评分比较,差异均无统计学意义(P>0.05)。各组患者并发症总发生率比较:Lvis/Lvis jr组低于Solitaire AB组和Neuroform组(P<0.05)。结论:Lvis/Lvis jr支架置入辅助弹簧圈栓塞治疗颅内动脉瘤的短期疗效及安全性优于Solitaire AB、Neuroform支架。Objective:To compare the efficacy and safety of Solitaire AB,Neuroform,Lvis/Lvis jr stent implantation assisted coil embolization in the treatment of intracranial aneurysms.Methods:The clinical data of 103 patients with intracranial aneurysms treated with coil embolization were retrospectively analyzed.According to the treatment plan,they were divided into Solitaire AB group(n=37),Neuroform group(n=34)and Lvis/Lvis jr group(n=32).The therapeutic effect and safety of the three groups were compared.Results:The stents in all three groups were positioned satisfactorily and released successfully,with a technical success rate of 100%.Immediately after surgery and 6 months after surgery,Raymond grades of the three groups were compared,and the differences were statistically significant(P<0.05),among which Lvis/Lvis jr group was better than Solitaire AB group and Neuroform group(P<0.05).After treatment,the expression levels of serum nerve growth factor(NGF)and S-100B protein in three groups were lower than before treatment(P<0.05),and Lvis/Lvis jr group was lower than Solitaire AB group and Neuroform group(P<0.05).6 months after surgery,there were no significant differences in the mean arterial flow velocity(Vm)before breath holding,Vm after breath holding,breath holding index(BHI)and modified Rankin scale(mRs)scores among three groups(P>0.05).The total incidence of complications among the three groups was statistically significant(P<0.05),and the Lvis/Lvis jr group was lower than that of Solitaire AB group and Neuroform group(P<0.05).Conclusion:The efficacy and safety of Lvis/Lvis jr stent implantation assisted by coil embolization in the treatment of intracranial aneurysms are superior to Solitaire AB and Neuroform stents.

关 键 词：Solitaire AB支架 NEUROFORM支架 Lvis/Lvis jr支架 弹簧圈栓塞 颅内动脉瘤 

分 类 号：R739.41[医药卫生—肿瘤]