宫颈癌根治术联合新辅助化疗与腔内近距离后装放疗治疗局部晚期宫颈癌的临床效果  

Clinical Effect of Radical Resection of Cervical Cancer Combined with Neoadjuvant Chemotherapy and Intracavitary Brachytherapy for Local Advanced Cervical Cancer

作　　者：姚涓 邵佳[1] 徐海波[1] 陈蕾[1] Yao Juan;Shao Jia;Xu Haibo;Chen Lei(Department of Gynecology and Oncology,Tumor Hospital Affiliated to Nantong University,Nantong 226361,Jiangsu Province,China)

机构地区：[1]南通大学附属肿瘤医院肿瘤妇科,江苏南通226361

出　　处：《中外医药研究》2024年第6期36-38,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：南通市科技计划项目(编号:JC22022107)。

摘　　要：目的:分析宫颈癌根治术联合新辅助化疗与腔内近距离后装放疗治疗局部晚期宫颈癌(LACC)的临床效果。方法:选取2014年1月—2018年6月南通大学附属肿瘤医院收治的Ⅰb2期、Ⅱa2期LACC患者86例作为研究对象,采用随机数字表法分为观察组(n=46)和对照组(n=40)。对照组行宫颈癌根治术,观察组在术前行新辅助化疗及腔内近距离后装放疗。比较两组手术情况、术后住院时间、不良反应发生情况及生存情况。结果:观察组手术时间、术后住院时间短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05);两组输尿管尿瘘、尿潴留、肾积水、肠梗阻、下肢静脉血栓、盆腔淋巴囊肿合并感染发生率比较,差异无统计学意义(P>0.05);两组3年无进展生存率、3年总生存率、中位生存时间比较,差异无统计学意义(P>0.05)。结论:宫颈癌根治术联合新辅助化疗与腔内近距离后装放疗治疗LACC的临床效果较好,可缩短手术治疗时间、减少术中出血量,加快术后恢复,且不会增加不良反应发生风险,不影响预后效果。Objective:To analyze the clinical effect of radical resection of cervical cancer combined with neoadjuvant chemotherapy and intracavitary brachytherapy in the treatment of locally advanced cervical cancer(LACC).Methods:A total of 86 patients with stageⅠb2 andⅡa2 LACC were selected as the study objects at Tumor Hospital Affiliated to Nantong University from January 2014 to June 2018,and were divided into observation group(n=46)and control group(n=40)by random number table method.The control group received radical resection of cervical cancer,and the observation group received neoadjuvant chemotherapy and intracavitary brachytherapy before surgery.Operation situation,postoperative hospital stay,occurrence of adverse reactions and survival were compared between the two groups.Results:The operation time and postoperative hospital stay in the observation group were shorter than those in the control group,and the intraoperative blood loss was less than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of ureteral fistula,urinary retention,hydronephrosis,intestinal obstruction,venous thrombosis of lower extremity and pelvic lymphocysts combined with infection between the two groups(P>0.05).There was no significant difference in 3-year progression-free survival,3-year overall survival and median survival time between the two groups(P>0.05).Conclusion:Radical resection of cervical cancer combined with neoadjuvant chemotherapy and intracavitary brachytherapy in the treatment of LACC has a good clinical effect,which can shorten the surgical treatment time,reduce intraoperative blood loss,accelerate postoperative recovery,and does not increase the risk of adverse reactions,and does not affect the prognosis.

关 键 词：宫颈癌 新辅助化疗 腔内近距离后装放疗 根治性手术 生存期 

分 类 号：R737.33[医药卫生—肿瘤]