基于“治未病”思想探讨中医药调控CREB蛋白防治阿尔茨海默病的作用机制研究进展  

The Mechanism of TCM Regulating CREB Protein in Preventing and Curing Alzheimer's Disease based on the Idea of"Preventive Treatment of Disease"

作　　者：张琳琳[1] 王东平[1] 向鑫 蒋晓杰 章洁 ZHANG Lin-lin;WANG Dong-ping;XIANG Xin;JIANG Xiao-jie;ZHANG Jie(The Second Affiliated Hospital of Tianjin University of traditional Chinese Medicine,Tian Jin 300250,China;Tianjin University of traditional Chinese Medicine,Tian Jin 301617,China)

机构地区：[1]天津中医药大学第二附属医院,天津300250 [2]天津中医药大学,天津301617

出　　处：《内蒙古中医药》2024年第2期148-152,共5页Inner Mongolia Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81873272);天津市中医药管理局中医中西医结合科研课题(2021108)。

摘　　要：阿尔茨海默病是常见的中枢神经退行性疾病,突触功能障碍导致神经元丢失是主要发病机制,然而突触可塑性改变导致的记忆减退在AD发病之前即可出现,这为在AD患者出现不可逆病理损害之前进行干预提供了可能。环磷酸腺苷效应元件结合蛋白(CREB)处于突触强化和记忆形成过程中多条激活通路的中心汇聚点,在人体学习记忆能力的维持中起着关键作用,本文通过回顾近年来同道有关CREB与学习记忆研究及中医药治疗AD现状的文献,分别从CREB与学习记忆的相关通路、参与AD发病机制的实验研究以及中医药防治AD与CREB蛋白的相关性等方面进行整理总结,以期为中医药以CREB蛋白为切入点改善记忆减退进而防治AD提供部分理论及实验依据。Alzheimer's disease is a common degenerative disease of central nervous system,the main pathogenesis is synaptic dysfunction which leads to neuronal loss.However,memory impairment caused by synaptic plasticity can occur before the onset of AD,which provides the possibility of intervention before irreversible pathological damage in AD patients.Cyclic adenosine monophosphate effector binding protein(CREB)is located at the central convergence point of multiple activation pathways in the process of synaptic strengthening and memory formation,and it plays a key role in the maintenance of human learning and memory ability.By reviewing the literature on the correlation between CREB and learning and memory and the current status of Chinese medicine in the treatment of AD in recent years,this paper summarized the relevant pathways of CREB and learning and memory,the relevant experimental studies on its participation in the pathogenesis of AD,and the correlation between the prevention and treatment of AD and CREB protein by Chinese medicine.In order to provide some theoretical and experimental basis for Chinese medicine to improve memory loss and prevent AD by using CREB protein as the breakthrough point.

关 键 词：环磷酸腺苷效应元件 阿尔茨海默病 中医药 治未病思想 研究进展 

分 类 号：R741.05[医药卫生—神经病学与精神病学]