温针灸联合药饼灸治疗腹泻型肠易激综合征疗效观察及对肠道菌群的影响  

Curative Effect of Warming-Needle Moxibustion Combined with Herbal Cake-Separated Moxibustion on Irritable Bowel Syndrome with Diarrhea and Its Effect on Intestinal Flora

作　　者：唐敏 刘鸿[1] 王丽琴 TANG Min;LIU Hong;WANG Liqin(Department of Acupuncture and Moxibustion,Lishui Hospital of Chinese Medicine,Lishui Zhejiang 323000,China)

机构地区：[1]丽水市中医院针灸科,浙江丽水323000

出　　处：《新中医》2024年第6期100-104,共5页New Chinese Medicine

摘　　要：目的:观察温针灸联合药饼灸治疗对腹泻型肠易激综合征(IBS-D)的临床疗效及对肠道菌群的影响。方法:选取100例IBS-D患者为研究对象,采用信封法随机分为观察组和对照组各50例。对照组在饮食结构、生活习惯调整的基础上给予双歧杆菌四联活菌片口服,观察组在对照组基础上给予温针灸、药饼灸治疗。比较2组临床疗效,以及治疗前后胃肠道激素[胃泌素(GAS)、胃动素(MTL)、血管活性肠肽(VIP)]水平、肠道菌群数量及中医证候评分。结果:治疗后,观察组总有效率为94.00%,对照组为76.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组GAS、MTL水平均较治疗前升高(P<0.05),VIP水平较治疗前降低(P<0.05);且观察组GAS、MTL水平高于对照组(P<0.05),VIP水平低于对照组(P<0.05)。治疗后,2组乳酸杆菌、双歧杆菌数量均较治疗前增加(P<0.05),肠球菌数量较治疗前减少(P<0.05);且观察组乳酸杆菌、双歧杆菌数量高于对照组(P<0.05),肠球菌数量低于对照组(P<0.05)。治疗后,2组粪便溏池、腹痛、神疲倦怠、纳呆、肠鸣矢气等中医证候评分均较治疗前降低(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。结论:温针灸联合药饼灸治疗IBS-D可有效改善患者胃肠道激素水平及中医证候,调节肠道菌群数量,临床疗效显著。Objective:To observe the clinical effect of warming-needle moxibustion combined with herbal cake-separated moxibustion on irritable bowel syndrome with diarrhea(IBS-D)and its effect on intestinal flora.Methods:A total of 100 cases of IBS-D patients were selected as study subjects and randomly divided into the observation group and the control group by using the envelope method,with 50 cases in each group.The control group was given Bifidobacterium Quadruple Viable Tablets orally on the basis of diet structure and lifestyle adjustment,and the observation group was additionally given warming-needle moxibustion and herbal cake-separated moxibustion on the basis of the control group.The levels of gastrointestinal hormones[(gastrin(GAS),motilin(MTL),and vasoactive intestinal peptide(VIP)],the number of intestinal flora,and traditional Chinese medicine(TCM)syndrome scores before and after treatment,as well as clinical effects,were compared between the two groups.Results:After treatment,the total effective rate was 94.00%in the observation group and 76.00%in the control group,the difference being significant(P<0.05).After treatment,the levels of GAS and MTL in the two groups were increased when compared with those before treatment(P<0.05),and ViP levels were decreased when compared with those before treatment(P<0.05):the levels of GAS and MTL in the observation group were higher than those in the control group(P<0.05),and the ViP level in the observation group was lower than that in the control group(P<0.05).After treatment,the number of Lactobacilli and Bifidobacteria in the two groups was increased when compared with that before treatment(P<0.05),and the number of enterococci was decreased when compared with that before treatment(P<0.05);the number of Lactobacilli and Bifidobacteria in the observation group was higher than that in the control group(P<0.05),and the number of Enterococci in the observation group was lower than that in the control group(P<0.05).After treatment,the scores of TCM syndromes including sloppy

关 键 词：腹泻型肠易激综合征 温针灸 药饼灸 胃肠道激素 肠道菌群 

分 类 号：R574.4[医药卫生—消化系统]