线粒体功能障碍与心血管疾病、缺血性脑卒中及慢性肾脏病关系的研究进展  

Research progress on the relationship between mitochondrial dysfunction and cardiovascular disease,ischemic stroke and chronic kidney disease

作　　者：罗婷[1,2] 邱令智 易东 鄢华 Luo Ting;Qiu Lingzhi;Yi Dong;Yan Hua(Department of Cardiology,Wuhan Asia Heart Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430022,China;Medical College,Wuhan University of Science and Technology,Wuhan 430081,China)

机构地区：[1]武汉科技大学附属武汉亚洲心脏病医院心内科,430022 [2]武汉科技大学医学部医学院,430081

出　　处：《中华脑血管病杂志（电子版）》2024年第1期60-63,共4页Chinese Journal of Cerebrovascular Diseases(Electronic Edition)

基　　金：湖北省卫生厅青年科技人才项目(QJX2012-35);武汉市科技局知识创新项目(2022020801010576)。

摘　　要：心血管疾病(CVD)、缺血性脑卒中(IS)及慢性肾脏病(CKD)是临床常见病,具有全因死亡率高、预后差的特点。线粒体作为细胞动力工厂,是保证细胞完整性和活力的关键。已有研究显示线粒体功能障碍与心、脑血管疾病和肾脏疾病密切相关,维持线粒体稳态是一种治疗CVD、IS和CKD有前景的策略。本综述总结了线粒体功能(线粒体生物发生、动力学、氧化应激和线粒体自噬)障碍及其与CVD、IS和CKD的关系,以期探索CVD、IS和CKD新的治疗方法。Cardiovascular disease(CVD),ischemic stroke(IS),and chronic kidney disease(CKD)are common clinical diseases with high all-cause mortality and poor prognosis.Mitochondria,as the power plant of cells,is the key to ensuring the integrity and vitality of cells.Previous studies have shown that mitochondrial dysfunction is closely related to cardiovascular diseases,cerebrovascular diseases,and kidney diseases.Therefore maintaining mitochondrial homeostasis is a promising strategy for treating CVD,IS,and CKD.This review summarized the malfunction of mitochondrial homeostasis(mitochondrial biogenesis,dynamics,oxidative stress,and mitophagy)and its relationship with CVD,IS,and CKD,in order to explore novel therapeutic strategies for CVD,IS,and CKD.

关 键 词：线粒体功能障碍 心血管疾病 缺血性脑卒中 慢性肾脏病 

分 类 号：R743.31[医药卫生—神经病学与精神病学]