基于常规MR和临床特征的ⅢC1p期宫颈癌患者预后相关因素初步研究  

Preliminary study of prognostic factors related to patients with stageⅢC1p cervical cancer based on conventional MR and clinical features

作　　者：田名可 秦凤英 孙心言 于庆 于韬 董越 TIAN Mingke;QIN Fengying;SUN Xinyan;YU Qing;YU Tao;DONG Yue(Department of Radiology,Cancer Hospital of Dalian University of Technology,Dalian,Liaoning Province 110801,China)

机构地区：[1]大连理工大学附属肿瘤医院放射科,辽宁大连110801

出　　处：《实用放射学杂志》2024年第3期406-410,共5页Journal of Practical Radiology

基　　金：大连理工大学-辽宁省肿瘤医院医工交叉联合基金项目(LD202119);2022年辽宁省应用基础研究计划项目(2022JH2101300074)。

摘　　要：目的评估ⅢC1p期宫颈癌患者无病生存期(DFS)相关MRI和临床病理预后因素.方法选取接受手术治疗的ⅢC1p期宫颈癌患者102例,根据随访生存状况分为进展组与非进展组,分析2组患者临床病理指标和MRI特征对于预后的影响因素.结果单因素分析结果显示,鳞状上皮细胞癌抗原(SCC-Ag)水平、T分期、淋巴结转移(LNM)位置与ⅢC1p期宫颈癌患者预后具有相关性(P<0.05);多因素分析结果显示T分期较晚、SCC-Ag>13 ng/mL、LNM位置≥3个为导致ⅢC1p期宫颈癌患者3年DFS显著下降的独立影响因素.结论SCC-Ag、T分期、LNM位置为ⅢC1p期宫颈癌患者3年DFS的独立影响因素.Objective To evaluate MRI and clinicopathological prognostic factors in predicting disease-free survival(DFS)of stageⅢC1p cervical cancer patients.Methods A total of 102 stageⅢC1p cervical cancer patients who underwent surgical treatment were selected.Based on survival status,stageⅢC1p cases were divided into two subgroups:progression group and no progression group.The influencing factors of clinicopathological indexes and MRI features on prognosis in the two groups were analyzed.Results The results of the univariate analysis showed that squamous cell carcinoma antigen(SCC-Ag)level,T stage and location of lymph node metastasis(LNM)were correlated with the prognosis of stageⅢC1p cervical cancer patients(P<0.05).Multivariate analysis results showed that late T stage,SCC-Ag>13 ng/mL,and LNM location≥3 were the high risk factors affecting the 3-year DFS decline in stageⅢC1p cervical cancer patients.Conclusion SCC-Ag,T stage,and LNM location are independent risk factors for 3-year DFS in stageⅢC1p cervical cancer patients.

关 键 词：宫颈癌 淋巴结转移 磁共振成像 

分 类 号：R737.33[医药卫生—肿瘤] R445.2[医药卫生—临床医学]