动脉自旋标记技术在孤独症谱系障碍伴或不伴全面发育迟缓中的应用  

Application of arterial spin labeling techniques in autism spectrum disorder with or without global developmental delay

作　　者：沈艳勇 赵鑫[1] 秦池 程美英[1] 任红瑞 孙永兵 张晓雪 王长浩 张小安[1] SHEN Yanyong;ZHAO Xin;QIN Chi;CHENG Meiying;REN Hongrui;SUN Yongbing;ZHANG Xiaoxue;WANG Changhao;ZHANG Xiao'an(Department of Medical Imaging,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Health Management,He'nan Provincial People's Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州大学第三附属医院医学影像科,河南郑州450052 [2]河南省人民医院健康管理科,河南郑州450003

出　　处：《实用放射学杂志》2024年第3期443-446,共4页Journal of Practical Radiology

基　　金：河南省2023年科技发展计划项目(232102311091)。

摘　　要：目的利用动脉自旋标记(ASL)技术测量并比较孤独症谱系障碍(ASD)、全面发育迟缓(GDD)和ASD伴GDD 3组儿童的脑血流量(CBF),并评估CBF值的诊断价值.方法采集3组儿童的ASL图像,并分别测量其额叶、颞叶、顶叶、枕叶、纹状体及丘脑感兴趣区(ROI)的CBF值.使用单因素方差分析或Kruskal-Wallis H秩和检验比较3组间CBF值的差异,使用受试者工作特征(ROC)曲线分析CBF值在区分ASD伴或不伴GDD中的效能.结果ASD伴GDD儿童在左侧额叶和右侧额叶的CBF值低于单独患ASD或GDD儿童,差异有统计学意义(P<0.05).左侧额叶和右侧额叶的CBF值在区分ASD伴或不伴GDD中具有较好的效能[曲线下面积(AUC)>0.7].结论ASL技术可以无创地评估ASD伴或不伴GDD儿童的CBF,有助于理解ASD伴GDD的病理生理机制以及提高诊断准确性.Objective To measure and compare the cerebral blood flow(CBF)of children with autism spectrum disorder(ASD),global developmental delay(GDD),and ASD with GDD groups via arterial spin labeling(ASL)technique,and to evaluate the diag-nostic value of CBF values.Methods ASL images of ASD,GDD,and ASD with GDD groups of children were firstly acquired,and the CBF values of frontal lobe,temporal lobe,parietal lobe,occipital lobe,striatum and thalamus region of interest(ROI)were fur-ther measured,respectively.One-way analysis of variance or Kruskal-Wallis H test was used to compare the differences in CBF values among these three groups,and the receiver operating characteristic(ROC)curve was used to analyze the efficacy of CBF values in distinguishing ASD with GDD from without GDD.Results ASD with GDD had significantly lower CBF values in the left and right frontal lobes than those with ASD or GDD alone,and the differences were statistically significant(P<0.05).The CBF values in the left and right frontal lobes effectively distinguished ASD with GDD from without GDD[area under the curve(AUC)>0.7].Conclusion ASL technique can noninvasively assess CBF in children with or without GDD,helping to understand the pathophysiology of ASD with GDD and improving diagnostic accuracy.

关 键 词：孤独症谱系障碍 全面发育迟缓 动脉自旋标记 脑血流量 

分 类 号：R748[医药卫生—神经病学与精神病学] R725[医药卫生—临床医学] R445.2