结直肠癌和不同类型结直肠息肉中LYVE-1标记的淋巴管密度及其临床意义  

Lymphatic vessel density of LYVE-1 labeling in colorectal cancer and different types of colorectal polyps and its clinical significance

作　　者：王海云 程永波[1] 解璇莹 WANG Haiyun;CHENG Yongbo;XIE Xuanying(First Department of Gastroenterology,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院消化一科,乌鲁木齐830054

出　　处：《山西医科大学学报》2024年第4期427-430,共4页Journal of Shanxi Medical University

基　　金：新疆维吾尔自治区高层次人才引进项目(人社明电[13]111号)。

摘　　要：目的探讨淋巴管内皮透明质酸受体-1(LYVE-1)标记的淋巴管密度(LVD)在结直肠癌和不同类型结直肠息肉中的差异及其临床意义。方法通过免疫组化法对60例结直肠息肉和18例结直肠癌中LYVE-1标记的淋巴管进行计数,分析结直肠癌和不同类型结直肠息肉中LVD的差异。结果结直肠癌中LVD显著高于结直肠息肉[(6.7±1.3)个vs(3.5±1.1)个,P<0.001]。不同类型的结直肠息肉中,炎性息肉中LVD低于腺瘤性息肉和锯齿状病变[(2.1±0.7)个vs(3.6±0.7)个,(4.1±1.1)个,P<0.05]。直径≥10 mm的息肉中LVD高于直径<10 mm的息肉[(3.6±1.1)个vs(2.7±1.0)个,P<0.05]。伴有异形增生的息肉中LVD显著高于不伴有异形增生的息肉[(4.0±1.0)个vs(3.0±1.0)个,P<0.001]。而LVD在不同性别、年龄、息肉位置方面差异均无统计学意义(P>0.05)。结论LVD有可能作为反映结直肠息肉预后的重要指标,为结直肠息肉患者术后随访间隔与结直肠癌的预测提供新的理论参考。Objective To investigate the difference of lymphatic vessel endothelial hyaluronic acid receptor-1(LYVE-1)labeled lymphatic vessel density(LVD)between colorectal cancer and different types of colorectal polyps and its clinical significance.Methods LYVE-1 labeled lymphatic vessels were counted by immunohistochemistry in 60 cases of colorectal polyps and 18 cases of colorectal cancer.The differences of LVD between colorectal cancer and different types of colorectal polyps were analyzed.Results The number of LVD in colorectal cancer was significantly higher than that in colorectal polyps(6.7±1.3 vs 3.5±1.1,P<0.001).LVD in inflammatory polyps was lower than that in adenomatous polyps and serrated lesions(2.1±0.7 vs 3.6±0.7,4.1±1.1,P<0.05).The number of LVD in polyps with diameter≥10 mm was higher than that in polyps with diameter<10 mm(3.6±1.1 vs 2.7±1.0,P<0.05).The LVD in polyps with dysplasia was significantly higher than that in polyps without dysplasia(4.0±1.0 vs 3.0±1.0,P<0.001).There was no significant difference in LVD between patients with different gender,age and polyp location(P>0.05).Conclusion LVD may be an important indicator for prognosis of colorectal polyps,which provide a new theoretical reference for the postoperative follow-up interval and prediction of colorectal cancer in patients with colorectal polyps.

关 键 词：结直肠息肉 结直肠癌 淋巴管密度 LYVE-1 预后 

分 类 号：R574[医药卫生—消化系统]