CD34^(+)内皮祖细胞和内皮抑素在肾细胞癌组织中的表达  

Expression of CD34^(+)endothelial progenitor cells and endostatin gene in renal cell carcinoma

作　　者：王雷阳 张力[1] 葛永超[1] 冯金顺[1] 刘萌萌[2] WANG Leiyang;ZHANG Li;GE Yongchao;FENG Jinshun;LIU Mengmeng(Department of Urology,the Third People’s Hospital of Zhengzhou City,Zhengzhou 450000,China;Department of Pathology,the Third People’s Hospital of Zhengzhou City,Zhengzhou 450000,China)

机构地区：[1]郑州市第三人民医院泌尿外科,河南郑州450000 [2]郑州市第三人民医院病理科,河南郑州450000

出　　处：《肿瘤基础与临床》2024年第1期21-23,共3页journal of basic and clinical oncology

摘　　要：目的探讨CD34^(+)内皮祖细胞(EPCs)、内皮抑素(ES)在肾细胞癌(RCC)组织中的表达及其在RCC进展中的意义。方法应用免疫组化S-P法检测96例RCC组织和20例正常肾组织中CD34^(+)EPCs、ES蛋白的表达,并对其与各临床病理特征的关系进行分析。结果RCC组织中CD34^(+)EPCs、ES阳性率均高于正常肾组织的(χ^(2)=47.126,P<0.001;χ^(2)=41.184,P<0.001)。RCC组织中CD34^(+)EPCs、ES表达的与肿瘤大小、临床分期、病理分级有关(χ^(2)=13.942,P<0.001;χ^(2)=21.009,P<0.001;χ^(2)=11.107,P=0.004)。RCC组织中CD34^(+)EPCs与ES表达呈正相关(r=0.226,P=0.027)。结论CD34^(+)EPCs和ES在RCC发生、发展的过程中有着重要的作用,两者联合检测对RCC患者诊断、治疗和预后评估有指导意义。Objective To study the expression of CD34^(+)endothelial progenitor cells(EPCs)and endostatin(ES)in renal cell carcinoma(RCC)tissues and their significance in the progression of RCC.Methods The expression of CD34^(+)EPCs and ES protein were detect by Immunohistochemical S-P method in 96 cases of RCC tissues and 20 cases of normal kidney tissues,and their correlation with various clinicopathological parameters were analyzed.Results The positive rates of CD34^(+)EPCs and ES in the RCC tissues were significantly higher than those in the normal kidney tissues(χ^(2)=47.126,P<0.001;χ^(2)=41.184,P<0.001).The expression of CD34^(+)EPCs and ES were correlated with the clinical stage,pathological grade and tumor dimension of RCC(χ^(2)=13.942,P<0.001;χ^(2)=21.009,P<0.001;χ^(2)=11.107,P=0.004).The expression of CD34^(+)EPCs and ES was positively correlation(r=0.226,P=0.027).Conclusion CD34^(+)EPCs and ES are important in the occurrence and development of RCC;they have a certain relationship with each other;detecting their expression in RCC has the guiding value for the diagnosis,treatment and prognosis evaluation of patients with RCC.

关 键 词：肾细胞癌 内皮祖细胞 内皮抑素 

分 类 号：R737.11[医药卫生—肿瘤]