宫颈癌患者术前血清内皮细胞TEK酪氨酸激酶水平与其临床特征及预后的关系  

Relationship between Preoperative Serum Endothelial TEK Tyrosine Kinase Level and Clinical Characteristics and Prognosis in Patients with Cervical Cancer

作　　者：林燕韦 陈丽[1] 黄玲[1] 李柱娟 石磊[1] 游正群 LIN Yan-wei;CHEN Li;HUANG Ling;LI Zhu-juan;SHI Lei;YOU Zheng-qun(Department of Gynecology,Jiangjin Hospital Affiliated to Chongqing University,Chongqing 402260,China)

机构地区：[1]重庆大学附属江津医院妇科,重庆402260

出　　处：《南昌大学学报（医学版）》2024年第2期47-51,60,共6页Journal of Nanchang University：Medical Sciences

基　　金：重庆市卫生健康委员会科研项目(CJ20210138)。

摘　　要：目的分析术前血清内皮细胞TEK酪氨酸激酶(TIE2)水平与宫颈癌患者临床特征及预后的关系。方法回顾性分析2013年1月至2022年6月在重庆大学附属江津医院进行宫颈癌根治术的346例患者的临床资料。随机选取10例进行Olink蛋白组学分析。使用试剂盒检测所有患者的术前TIE2水平,分析患者TIE2水平与临床资料之间的关系。受试者工作特征曲线(ROC)分析血清TIE2对肿瘤复发的临界值。Kaplan-Meier方法分析无进展生存期(PFS)和总生存期(OS)。Cox比例风险模型评估患者PFS和OS的影响因素。结果Olink蛋白质组学显示宫颈癌根治术后血清TIE2、S100A4、MSLN、FGFBP1、ICOSLG和CASP8水平降低(均P<0.05)。术前血清TIE2水平与患者FIGO分期、肿瘤大小、深部肌层浸润、LVSI、宫旁浸润、阴道边缘侵入、淋巴结转移和盆腔外复发相关(均P<0.05)。ROC分析显示,曲线下面积为0.768(95%CI=0.718~0.791,P<0.001),约登指数为2.75 ng·mL^(-1),敏感度为73.2%,特异度为70.3%。血清TIE2水平≤2.75 ng·mL^(-1)患者的中位PFS和OS优于血清TIE2水平>2.75 ng·mL^(-1)患者(均P<0.001)。Cox比例风险模型显示,LVSI和血清TIE2水平>2.75 ng·mL^(-1)是患者PFS和OS的独立危险因素(P<0.001)。结论术前血清TIE2水平与宫颈癌患者临床特征有关;术前血清TIE2>2.75 ng·mL^(-1)的患者预后更差。Objective To investigate the relationship between preoperative serum endothelial TEK tyrosine kinase(TIE2)level and clinical characteristics and prognosis in patients with cervical cancer.Methods Clinical data of 346 patients who underwent radical surgery for cervical cancer in our hospital between January 2013 and June 2022 were retrospectively analyzed.Ten cases were randomly selected for Olink proteomics analysis.Serum TIE2 levels were measured using immunoradiometric assay to analyze the relationship between TIE2 levels and clinical data.The cutoff value of serum TIE2 for tumor recurrence was calculated using the receiver operating characteristic(ROC)curve.Progression-free survival(PFS)and overall survival(OS)were analyzed using the Kaplan-Meier method.Cox proportional hazard model was used to evaluate the factors affecting PFS and OS.Results Olink proteomics showed that TIE2,S100A4,MSLN,FGFBP1,ICOSLG and CASP8 were decreased after radical resection for cervical cancer(P<0.05).Preoperative serum TIE2 level was correlated with FIGO stage,tumor size,deep myometrial invasion,LVSI,parametrial invasion,vaginal margin invasion,lymphatic metastasis,and extrapelvic recurrence(P<0.05).The area under the ROC curve was 0.768(95%CI=0.718~0.791,P<0.001).The Youden index,sensitivity and specificity were 2.75 ng·mL^(-1),73.2%and 70.3%,respectively.The median PFS and OS in patients with serum TIE2 level≤2.75 ng·mL^(-1)were longer than those in patients with serum TIE2 level>2.75 ng·mL^(-1)(P<0.001).Cox proportional hazard model showed that serum LVSI and TIE2 level>2.75 ng·mL^(-1)were independent risk factors for PFS and OS in patients undergoing radical surgery for cervical cancer(P<0.001).Conclusion Preoperative serum TIE2 level is associated with clinical characteristics of patients with cervical cancer,and patients with preoperative TIE2 level>2.75 ng·mL^(-1)have a worse prognosis.

关 键 词：宫颈癌 根治术 内皮细胞TEK酪氨酸激酶 预后 

分 类 号：R737.33[医药卫生—肿瘤]