Cronkhite-Canada综合征2例并文献复习  

Cronkhite-Canada Syndrome:Two Case Reports and Review of the Literature

作　　者：张泽雨 康其乐 郭驰伟 王农荣[2] 谢桂生[2] 付小君[2] 斯轶凡[2] ZHANG Ze-yu;KANG Qi-le;GUO Chi-wei;WANG Nong-rong;XIE Gui-sheng;FU Xiao-jun;SI Yi-fan(The Fourth Clinical Medical College,the Fourth Affiliated Hospital of Nanchang University,Nanchang 330006,China;Department of Gastroenterology,the Fourth Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第四临床医学院,南昌330002 [2]南昌大学第四附属医院消化内科,南昌330002

出　　处：《南昌大学学报（医学版）》2024年第2期98-104,共7页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)的临床特征、治疗方法及预后。方法收集南昌大学第四附属医院消化内科收治的2例CCS患者的临床资料,结合相关文献,对其诊疗、转归以及长期消化内镜的随访资料进行分析。结果2例患者均以胃息肉病变为突出表现。例1于2013年5月确诊CCS并结肠癌,予外科手术、内镜下部分息肉切除术及营养支持治疗后,患者营养状况明显好转,确诊后2年间进行6次胃镜随访,2015年4月确诊胃窦恶性溃疡,2017年7月死亡。例2于2019年6月入院时诊断不明,结合患者其他症状及体征,诊断为CCS,采用激素治疗效果不佳,后因病情进展行全胃切除,术后随访2年,目前病情稳定。结论CCS病情多呈进行性加重,具有恶变趋势,治疗上以糖皮质激素为主,必要时可考虑切除严重病变部位,长期消化内镜下随访有助于诊断疾病及发现早期癌变。Objective To study the clinical characteristics,treatment and prognosis of Cronkhite-Canada syndrome(CCS).Methods Clinical data of two patients with CCS admitted to the Department of Gastroenterology of the Fourth Affiliated Hospital of Nanchang University were collected,and their diagnosis and treatment,regression,and long-term gastrointestinal endoscopic follow-up data were analyzed in conjunction with relevant literature.Results Both cases were highlighted by gastric polyp lesions.The first patient was diagnosed with CCS and colon cancer in May 2013,and was treated with endoscopic partial polypectomy;with nutritional support,the patient’s status improved significantly;6 gastroscopic follow-ups were performed during the next 2 years;gastric sinus malignant ulceration was diagnosed in April 2015,and he died in July 2017.The second patient was admitted to the hospital in June 2019 with an unknown diagnosis;combined with other symptoms and signs,he was confirmed with CCS and treated with hormone therapy,but with poor result;total gastrectomy was performed due to the disease progression;he has been followed up for 2 years now,with his conditions stable.Conclusion CCS can become malignant with progressive exacerbation.Glucocorticosteroids are the mainstay of treatment,and resection of severe lesions can be considered when necessary.Long-term gastrointestinal endoscopic follow-up can be helpful in the diagnosis of the disease and the detection of early cancerous lesions.

关 键 词：CRONKHITE-CANADA综合征 外胚层改变 胃镜随访 病例报告 

分 类 号：R573[医药卫生—消化系统] R574[医药卫生—内科学]