颈动脉斑块血流动力学成像技术及新进展  

Hemodynamic Imaging Techniques and New Advances in Carotid Artery Plaques

作　　者：李璐 胥海洋 孙雨蒙 李婷婷[1] 于薇[1] LI Lu;XU Haiyang;SUN Yumeng;LI Tingting;YU Wei(Department of Medical Imaging,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart Lung and Blood Vessel Diseases,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院影像科,北京市心肺血管疾病研究所,北京100029

出　　处：《磁共振成像》2024年第4期214-218,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：北京市自然科学基金项目(编号:7222047)。

摘　　要：颈动脉粥样硬化性狭窄是引起缺血性脑卒中(ischemic stroke,IS)的主要疾病之一,尽早发现狭窄并识别易损斑块可以显著改善疗效,降低致死率和致残率。血流动力学改变与斑块的形成、发展、破裂有着密切关系。利用血流动力学参数来评估动脉粥样硬化斑块破裂的风险及指导临床治疗方式的选择已经成为动脉粥样硬化精确诊疗的研究焦点。然而,血流动力学参数与斑块相互作用的机制尚未被完全阐明,血流动力学相关影像学技术也未广泛开展。本文通过对既往文献进行回顾,进一步梳理颈动脉斑块血流动力学的影像进展,以及血流动力学变化与斑块形成、发展、破裂之间的相互作用机制,并探讨了这些特征与缺血性卒中的关系,旨在评估综合分析斑块成分和血流动力学对颈动脉粥样硬化性狭窄引起脑卒中事件的预测价值。Carotid atherosclerotic stenosis is one of the main diseases causing ischemic stroke(IS),and early detection of stenosis and identification of vulnerable plaques can significantly improve the efficacy and reduce the mortality and disability rates.Hemodynamic changes are closely related to the formation,development,and rupture of plaques.The use of hemodynamic parameters to assess the risk of atherosclerotic plaque rupture and guide the selection of clinical treatment methods has become the focus of research on the precise diagnosis and treatment of atherosclerosis.However,the mechanism of the interaction between hemodynamic parameters and plaques has not been fully elucidated,and hemodynamic imaging techniques have not been widely developed.This article reviews the previous literature to further sort out the imaging progress of carotid plaque hemodynamics,as well as the interaction mechanism between hemodynamic changes and plaque formation,development and rupture,and discuss the relationship between these features and IS,aiming to evaluate the predictive value of plaque composition and hemodynamics in stroke events caused by carotid atherosclerotic stenosis.

关 键 词：颈动脉粥样硬化 血流动力学 计算流体动力学 四维血流磁共振成像 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R543.4[医药卫生—诊断学] R743.3[医药卫生—临床医学]