苦参碱-脂肪酸低共熔溶剂的制备及物性  

Preparation and Physical Properties of Matrine-Fatty Acid Deep Eutectic Solvent

作　　者：杨清华 王小永[1] 殷天翔[1] YANG Qinghua;WANG Xiaoyong;YIN Tianxiang(School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China)

机构地区：[1]华东理工大学化学与分子工程学院,上海200237

出　　处：《华东理工大学学报（自然科学版）》2024年第2期199-207,共9页Journal of East China University of Science and Technology

基　　金：国家自然科学基金(21773063,2273022)。

摘　　要：构建了一系列基于苦参碱和脂肪酸的低共熔溶剂(Deep Eutectic Solvent,DES),探讨了脂肪酸烷基链长、氢键供体(HBD)与氢键受体(HBA)的物质的量之比对DES的理化性质的影响。结果表明:DES的密度、表面张力、电导率、极性随脂肪酸烷基链长度的增加而降低,黏度随脂肪酸链长的增大而增加;密度、表面张力和黏度随苦参碱与脂肪酸物质的量之比的减小而降低,电导率则随苦参碱与脂肪酸物质的量之比的减小而增加,上述不同的变化趋势源于苦参碱和脂肪酸分子之间相互作用的变化。Deep eutectic solvents(DESs),as a new type of green solvent,have shown great advantages of easy preparation,no purification needed after synthesis and great potential for application in various fields.A new type of drug delivery system called therapeutic deep eutectic solvent(THEDES)was developed when combining active pharmaceutical ingredients(APIs)into DES.Matrine has been shown great potential applications due to its antiinflammatory,antioxidant,and antibacterial functions.This paper constructed a series of new THEDES based on matrine and fatty acids,and deeply studied the effects of alkyl chain length of fatty acids,the molar ratio of hydrogen bond donor(HBD)to hydrogen bond receptor(HBA)on the physicochemical properties of DES.The results showed that the density,surface tension,conductivity and polarity of DES declined with the increase of alkyl chain length of fatty acids,while the viscosity of DES increased with the increase of chain length of fatty acids.In addition,the density,surface tension and viscosity declined with the decrease of the molar ratio of matrine to fatty acid,while the conductivity increased with the decrease of the molar ratio of matrine to fatty acid.These different trends were due to the changes in the interaction between matrine and fatty acid molecules.The results of this work provided an important basis for the development and application of matrine-based therapeutic eutectic solvents.

关 键 词：低共熔溶剂 苦参碱 脂肪酸 Kamlet-Taft参数 氢键 

分 类 号：O645.16[理学—物理化学]