胃癌组织中CCNB1、CDK1的表达及其与总体生存率的相关性  

Expression of CCNB1 and CDK1 in gastric cancer tissues and their correlation with overall survival

作　　者：王娜[1] 杨迷玲 徐宪伟 Wang Na;Yang Miling;XU Xianwei(Department of Pathology,Zhengzhou People's Hospital,The Fifth Clinical College of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第五临床医学院(郑州人民医院)病理科,河南郑州450000

出　　处：《四川生理科学杂志》2024年第4期718-720,共3页Sichuan Journal of Physiological Sciences

基　　金：河南省医学科技攻关计划省部共建项目(编号:2018010043)。

摘　　要：目的:观察胃癌组织中细胞周期蛋白B1(Cyclin B1,CCNB1)和细胞周期蛋白质依赖激酶1(Cyclin-dependent kinases1,CDK1)的表达与患者总体生存率之间的关系。方法:回顾分析2017年9月至2023年9月于本院完成胃癌根治术和术后5年随访的58例胃癌患者资料,查阅资料,记录癌组织与癌旁组织的CCNB1、CDK1表达情况,重点分析癌组织CCNB1和CDK1表达与胃癌患者术后总体生存率的关系。结果:癌组织CCNB1、CDK1阳性表达占比高于癌旁组织(P<0.05);不同浸润程度患者的CDK1阳性占比比较差异有统计学意义(P<0.05),不同淋巴结转移、肿瘤转移(Tumor Node Metastasis,TNM)分期和分化程度胃癌患者的CCNB1、CDK1阳性占比比较差异有统计学意义(P<0.05);58例患者病死42例,病死率为72.41%;病死组癌组织CCNB1、CDK1阳性占比高于存活组(P<0.05);经相关性检验,胃癌患者癌组织CCNB1和CDK1阳性表达与生存情况(病死)存在正相关关系(r>0,P<0.05)。结论:CCNB1、CDK1在胃癌癌组织中呈异常表达,这种异常表达可能与患者术后总体生存率有关,提示术后病死高风险,应引起临床重视。Objective:To investigate the relationship between the expression of Cyclin B1(CCNB1)and cyclin-dependent kinases1(CDK1)in gastric cancer tissues and the overall survival rate of patients.Methods:The data of 58 patients with gastric cancer who completed radical gastrectomy and 5-year follow-up in our hospital from September 2017 to September 2023 were retrospectively analyzed.The expression of CCNB1 and CDK1 in cancer tissues and adjacent tissues were recorded by referring to the data,and the relationship between the expression of CCNB1 and CDK1 in cancer tissues and the overall postoperative survival rate of patients with gastric cancer was analyzed.Results:The positive expressions of CCNB1 and CDK1 in cancer tissues were higher than those in adjacent tissues(P<0.05).The proportion of CDK1 positive in patients with different degrees of invasion was different(P<0.05),and the proportion of CCNB1 and CDK1 positive in gastric cancer patients with different lymph Node Metastasis,Tumor Node Metastasis(TNM)stage and differentiation was different(P<0.05).Of the 58 patients,42 died,and the fatality rate was 72.41%.The positive proportion of CCNB1 and CDK1 in death group was higher than that in survival group(P<0.05).The correlation test showed that the positive expression of CCNB1 and CDK1 in cancer tissues was positively correlated with survival(disease and death)(r>0,P<0.05).Conclusion:CCNB1 and CDK1 are abnormally expressed in gastric cancer tissues,which may be related to the overall survival rate of patients after surgery,indicating a high risk of postoperative death,which should be paid clinical attention.

关 键 词：胃癌 细胞周期蛋白B1 细胞周期蛋白依赖性激酶1 生存率 相关性 

分 类 号：R735.2[医药卫生—肿瘤]