HPV、TCT检查在子宫颈癌前病变筛查中的价值分析  

Value analysis of HPV and TCT in screening of cervical precancerous lesions

作　　者：南静 王静 Nan Jing;Wang Jing(Department of Pathology,The Second People's Hospital of Lingbao,Lingbao 472500,Henan,China;Department of Obstetrics and Gynecology,The Second People's Hospital of Lingbao,Lingbao 472500,Henan,China)

机构地区：[1]灵宝市第二人民医院病理科,河南灵宝472500 [2]灵宝市第二人民医院妇产科,河南灵宝472500

出　　处：《四川生理科学杂志》2024年第4期867-869,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:分析人乳头瘤病毒(Human Papilloma Virus,HPV)、宫颈液基细胞学检查(Thin-Cytologic Test,TCT)在子宫颈病变筛查中的临床价值。方法:选取2020年7月至2023年7月期间在本院进行子宫颈癌前病变筛查的疑似子宫颈癌前病变患者2614例作为研究对象。所有患者均进行HPV与TCT检查,将病理学的检验结果作为本研究的金标准,比较HPV与TCT这两种检验方法的检查结果,分析HPV、TCT检查分别在子宫颈癌前病变早期筛查中的实际临床价值。结果:2614例疑似子宫颈癌前病变患者中经病理检查,阳性检出率为8.22%。HPV检查阳性检出率为8.11%,与病理学检验结果间的Kappa值为0.6855;经TCT检查阳性检出率为2.98%,与病理学检验结果间的Kappa值为0.4182;联合检查阳性检出率为8.19%,与病理学检验结果间的Kappa值为0.7383;对子宫颈癌前病变诊断的检查灵敏度、特异度、准确度、阳性预测值和阴性预测值分别如下,HPV检查为69.77%、97.62%、95.33%、72.46%、97.30%;TCT检查为30.23%、99.46%、93.46%、83.33%、94.09%;联合检查为74.88%、97.79%、95.91%、75.23%、97.75%;结论:HPV和TCT检查均适用于在早期子宫颈癌前病变的筛查,且其更加简单快捷,对患者的创伤较小,推荐在临床使用。Objective:To analyze the clinical value of Human Papilloma Virus(HPV)and Thin-Cytologic Test(TCT)in screening cervical lesions.Methods:A total of 2614 patients with suspected cervical prelesions who underwent screening for cervical prelesions in our hospital from July 2020 to July 2023 were selected as the study objects.All patients underwent HPV and TCT examination,and pathological examination results were taken as the gold standard of this study.The results of HPV and TCT examination were compared,and the actual clinical value of HPV and TCT examination in the early screening of cervical precancerous lesions was analyzed.Results:The positive rate of 2614 patients with suspected precancerous lesions of cervical cancer was 8.22%.The positive rate of HPV was 8.11%,and the Kappa value between HPV and pathological test was 0.6855.The positive rate of TCT examination was 2.98%,and the Kappa value between TCT examination and pathological examination was 0.4182.The positive rate of combined examination was 8.19%,and the Kappa value between the combined examination and pathological examination was 0.7383.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value for the diagnosis of cervical precancerous lesions were 69.77%,97.62%,95.33%,72.46%,97.30%for HPV.The results of TCT examination were 30.23%,99.46%,93.46%,83.33%and 94.09%.The joint examination was 74.88%,97.79%,95.91%,75.23%,97.75%;Conclusion:Both HPV and TCT are suitable for the screening of precancerous lesions of cervical cancer in the early stage,and they are simpler and faster,less invasive to patients,and are recommended for clinical use.

关 键 词：人乳头瘤病毒 宫颈液基细胞学检查 子宫颈癌前病变 早期筛查 

分 类 号：R737.33[医药卫生—肿瘤]