基于线粒体功能及能量代谢探讨潘氏细胞与肠道干细胞的交互作用及中医药作用的可能靶点研究进展  

Advances in Exploring the Interaction between Paneth Cells and Intestinal Stem Cells and Possible Targets for Traditional Chinese Medicine Based on Mitochondrial Function and Energy Metabolism

作　　者：罗国樑 张馨丹 唐太春[1] 朱焰 汪淑婷 陈敏[1] LUO Guoliang;ZHANG Xindan;TANG Taichun;ZHU Yan;WANG Shuting;CHEN Min(Hospital of Chengdu University of Traditional Chinese Medicine/Clinical Medicine School of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)

机构地区：[1]成都中医药大学附属医院/临床医学院,四川省成都市610072

出　　处：《中国全科医学》2024年第23期2864-2868,共5页Chinese General Practice

基　　金：国家自然科学基金资助项目(82274529);科研能力提升“百人计划”(20-B05)。

摘　　要：肠道干细胞与潘氏细胞相互作用,共同维护肠道稳态及功能,肠道干细胞及潘氏细胞交互过程受到线粒体相关功能及能量转化的调控。中医药治疗肠道疾病的独特优势也体现在其对于线粒体及能量代谢的作用方面。本文探讨线粒体功能及能量代谢对肠道干细胞、潘氏细胞交互的影响,并探索中医药治疗肠道疾病中与线粒体相关的可能靶点,总结中医药对线粒体及能量代谢的调节作用,进而恢复肠道稳态,缓解疾病。以期为基于线粒体研究肠道干细胞、潘氏细胞的中医药治疗相关研究提供一定的参考及理论依据。Intestinal stem cells and Paneth cells interact with each other to maintain intestinal homeostasis and function,the interaction between intestinal stem cells and Paneth cells is regulated by mitochondria-related functions and energy conversion.The unique advantages of traditional Chinese medicine(TCM)in the treatment of intestinal diseases are also reflected in its effects on mitochondria and energy metabolism.This paper explores the influence of mitochondrial function and energy metabolism on the interaction between intestinal stem cells and Paneth cells,as well as the possible targets related to mitochondria in the treatment of intestinal diseases by TCM,summarizes the regulatory effects of TCM on mitochondria and energy metabolism,thereby restoring intestinal homeostasis and alleviating disease,with an aim to provide reference and theoretical basis for the research related to the TCM treatment of intestinal stem cells and Paneth cells based on mitochondria.

关 键 词：肠道干细胞 潘氏细胞 线粒体 能量代谢 中医药 

分 类 号：R574[医药卫生—消化系统]