他汀类与抗血小板聚集药物联合应用于缺血性脑血管病治疗中的效果分析  

Effect analysis of statins combined with antiplatelet drugs in the treatment of ischemic cerebrovascular disease

作　　者：于海游 YU Hai-you(Department of Neurology,Linshu County People's Hospital,Linyi 276700,China)

机构地区：[1]临沭县人民医院神经内科,276700

出　　处：《中国实用医药》2024年第7期102-105,共4页China Practical Medicine

摘　　要：目的分析他汀类与抗血小板聚集药物联合应用于缺血性脑血管病治疗中的效果。方法104例缺血性脑血管病患者,根据就诊日期单双号分为对照组和联合组,每组52例。对照组应用抗血小板聚集药物治疗,联合组应用他汀类与抗血小板聚集药物联合治疗。比较两组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数、血脂指标[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、C反应蛋白(CRP)水平、内膜中层厚度(IMT)及临床效果。结果治疗后,联合组患者NIHSS评分(8.73±3.46)分低于对照组的(14.02±4.21)分,Barthel指数(72.72±7.53)分高于对照组的(54.86±6.33)分(P<0.05)。治疗后,联合组患者TG(1.21±0.34)mmol/L、TC(2.70±0.22)mmol/L、LDL-C(1.57±0.38)mmol/L低于对照组的(1.59±0.52)、(3.63±0.58)、(2.12±0.49)mmol/L,HDL-C(1.86±0.72)mmol/L高于对照组的(1.59±0.48)mmol/L(P<0.05)。治疗后,联合组患者CRP(2.07±0.39)mg/L、IMT(0.63±0.14)mm低于对照组的(5.46±1.26)mg/L、(0.85±0.19)mm(P<0.05)。联合组临床总有效率为94.23%,高于对照组的80.77%(P<0.05)。结论缺血性脑血管病治疗中采用他汀类和抗血小板聚集类药物联合治疗可提高神经功能、日常生活能力,改善血脂水平,从而帮助患者获得更为满意的疗效和预后。Objective To analyze the effect of statins combined with antiplatelet drugs in the treatment of ischemic cerebrovascular disease.Methods 104 patients with ischemic cerebrovascular disease were divided into a control group and a combination group according to the visit dates(odd and even number),with 52 cases in each group.The control group was treated with antiplatelet drugs,and the combination group was treated with statins and antiplatelet drugs.Patients in both groups were compared in terms of National Institutes of Health Stroke Scale(NIHSS)score,Barthel index,blood lipid indicators[triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],C-reactive protein(CRP)levels and intima-media thickness(IMT)before and after treatment,and clinical effects.Results After treatment,the combination group had lower NIHSS score of(8.73±3.46)points than(14.02±4.21)points in the control group,and higher Barthel index of(72.72±7.53)points than(54.86±6.33)points in the control group(P<0.05).After treatment,the combination group had TG of(2.70±0.22)mmol/L,TC of(1.21±0.34)mmol/L,LDL-C of(1.57±0.38)mmol/L,which were lower than(1.59±0.52),(2.12±0.49),(3.63±0.58)mmol/L in the control group;the combination group had higher HDL-C of(1.86±0.72)mmol/L than(1.59±0.48)mmol/L in the control group(P<0.05).After treatment,the combination group had CRP of(2.07±0.39)mg/L and IMT of(0.63±0.14)mm,which were lower than(5.46±1.26)mg/L and(0.85±0.19)mm in the control group(P<0.05).The total effective rate of the combination group was 94.23%,which was higher than 80.77%of the control group(P<0.05).Conclusion In the treatment of ischemic cerebrovascular disease,the combination of statins and antiplatelet drugs can improve nerve function,activities of daily living and blood lipid level,so as to help patients obtain more satisfactory efficacy and prognosis.

关 键 词：缺血性脑血管病 他汀类 抗血小板聚集药物 血脂水平 临床效果 

分 类 号：R743[医药卫生—神经病学与精神病学]