2019-2022年海南省女性高危型人乳头瘤病毒感染及宫颈癌和癌前病变筛查报告  

Report on high-risk human papillomavirus infection and screening for cervical cancer and precancerous lesions among women in Hainan Province between 2019 and 2022

作　　者：窦倩如 黄翠敏 曹霞 王晓黎 范霞林 吴桂花 孔令婉 粘惠瑜 程冷眉 刘燊 樊利春 DOU Qian-ru;HUANG Cui-min;CAO Xia;WANG Xiao-li;FAN Xia-lin;WU Gui-hua;KONG Ling-wan;NIAN Hui-yu;CHENG Leng-mei;LIU Shen;FAN Li-chun(Hainan Women and Children's Medical Center,Haikou,Hainan 570206,China)

机构地区：[1]海南省妇女儿童医学中心保健部,海南海口570206

出　　处：《中华医院感染学杂志》2024年第8期1210-1216,共7页Chinese Journal of Nosocomiology

基　　金：海南省自然科学基金项目(820QN409);海南省临床医学中心建设项目资助(琼卫医函〔2021〕75号)。

摘　　要：目的分析海南省女性高危型人乳头状瘤病毒(HR-HPV)感染状况,及其与宫颈癌和癌前病变的关系。方法数据来源于2019-2022年海南省妇女免费宫颈癌筛查项目,所有对象均进行HPV初筛,并根据结果进行后续的细胞学、阴道镜和宫颈组织病理学检查。结果2019-2022年海南省共947852例适龄女性纳入研究,HR-HPV的感染率为10.91%,其中HPV16、18和其他12型的感染率为1.17%、0.70%和9.66%;HR-HPV感染率较高的民族为苗族、其他少数民族和壮族,感染率分别为14.78%、11.43%和11.33%(P<0.05);HR-HPV感染率较高的年龄段为20~岁、55~64岁和25~岁,感染率分别为14.87%、12.45%和11.54%(P<0.05);各市县HR-HPV总体感染率、HPV16、18和其他12型的感染率不同(P<0.05);2019-2022年海南省宫颈癌前病变的检出率为304.79/10万,宫颈癌的检出率为15.40/10万;在HPV阳性者中,宫颈癌的检出率在HPV16型、16+18型和18型阳性者中较高(P<0.05);宫颈癌的检出率在55~64岁和45~岁者中较高(P<0.05)。结论海南省不同民族、年龄、地区女性HR-HPV分布不同。政府部门加大投入,通过进一步扩大基于HPV初筛的宫颈癌筛查范围,将低龄女孩HPV疫苗接种纳入政府免费项目,有望推进宫颈癌消除并缩小地区差异。OBJECTIVE To analyze the status of high-risk human papillomavirus(HR-HPV)infection and its asso-ciation with cervical cancer and cervical precancerous lesions among women in Hainan Province.METHODS Data were obtained from the free cervical cancer screening programme for women in Hainan Province between 2019 and 2022.The specimens from all women were used for initial HPV screening and subsequent cytological examination,cytology,colposcopy and cervical histopathological examination were performed on those based on the results of the initial screening.RESULTS A total of 947852 women in Hainan Province were enrolled in the study from 2019 to 2022,and the infection rate of HR-HPV was 10.91%,of which the infection rates of HPV 16,HPV 18,and other 12 types of HPV were 1.17%,0.70%,and 9.66%,respectively.The ethnic groups with the highest rates of HR-HPV infection were the Miao,other ethnic minorities and Zhuang,with the rates of 14.78%,11.43%,and 11.33%,respectively(P<0.05).The age groups presenting the highest HR-HPV infection rates were 20-,55-64 and 25-years old,with prevalence rates of 14.87%,12.45%,12.54%and 11.33%,respectively(P<0.05).Over-all HR-HPV infection rates of HPV 16,HPV 18 and other 12 types of HPV varied by city and county(P<0.05).The detection rate of cervical precancerous lesions in Hainan Province from 2019-2022 was 304.79/100000,and the detection rate of cervical cancer was 15.40/100000.Among HPV-positive individuals,the detection rates of cervical cancer were higher among those with HPV16,HPV16/18 and HPV18 infection(P<0.05).The detection rates of cervical cancer were higher among those aged 55-64 years and 45-years(P<0.05).CONCLUSION The distribution of HR-HPV infection among women of different ethnic groups,ages and regions in Hainan Province varies.The government departments should increase investment in further expanding primary HPV-based cervical cancer screening and incorporating HPV vaccination for low-age girls into free government programs,in order to eliminate and reduce regional dispariti

关 键 词：海南省 宫颈癌 癌前病变 高危型人乳头瘤病毒 感染 

分 类 号：R737.33[医药卫生—肿瘤]