筑青生命活素固体饮料对小鼠学习记忆障碍的影响  

Effect and Mechanism of Zhuqing Vitalin Solid Beverage on Learning and Memory Impairment in Mice

作　　者：龚频[1] 徐珂 马天有[2] 窦建卫[3] GONG Pin;XU Ke;MA Tianyou;DOU Jianwei(College of Food Science and Engineering,Shaanxi University of Science and Technology,Xi'an 710021;School of Public Health,Xi'an Jiaotong University,Xi'an 710065;School of Pharmacy,Xi'an Jiaotong University,Xi'an 710065)

机构地区：[1]陕西科技大学食品科学与工程学院,西安710021 [2]西安交通大学公共卫生学院,西安710065 [3]西安交通大学药学院,西安710065

出　　处：《食品工业》2024年第3期130-135,共6页The Food Industry

基　　金：陕西省创新能力支撑计划(2023-CXPT-19)。

摘　　要：文章探究了筑青生命活素固体饮料对小鼠学习记忆障碍的影响。将c57bl/6雄性小鼠随机分为空白组、模型组、低剂量组、中剂量组、高剂量组,每组10只小鼠,连续灌胃给药15 d;第23天,给药组与模型组小鼠腹腔注射氢溴酸东莨菪碱(2 mg/kg)以建立学习记忆障碍模型。通过跳台试验和Morris水迷宫试验对小鼠空间学习记忆能力进行评估,检测各组小鼠脑组织中各种指标的含量。筑青生命活素固体饮料可以改善东莨菪碱所致的痴呆,但这种改善效果不能长期维持,同时能够增加小鼠脑组织和血清中SOD、CAT活性,减少MDA含量,增强DPPH清除能力,减少羟自由基含量,且增加Ach含量。筑青生命活素固体饮料能改善东莨菪碱所致痴呆小鼠的学习记忆障碍,配方中覆盆子可能发挥主要作用。To explore the effect and mechanism of Zhuqing vitalin solid beverage on learning and memory impairment in mice,c57bl/6 male mice are randomly divided into blank group,model group,low-dose group,medium-dose group and high-dose group,with 10 mice in each group.Continuous intragastric administration for 15 days;On day 23,mice in the administration group and model group are intraperitoneally injected scopolamine hydrobromide(2 mg/kg) to establish a learning and memory impairment model.The spatial learning and memory ability of mice are evaluated by skip test and Morris water maze test,and the oxidative damage indexes in brain tissue of mice in each group are detected.The spatial learning and memory ability of mice are evaluated by jumping bench test and Morris water maze test,and the contents of various indexes in the brain tissue of mice in each group are detected.Chuqing Life Actin solid drink can improve the dementia induced by scopolamine,but the improvement effect cannot be maintained for a long time.At the same time,it can increase the activities of SOD and CAT in brain tissue and serum of mice,reduce the content of MDA,enhance the scavenging ability of DPPH,reduce the content of hydroxyl free radicals,and increase the content of Ach.Zhugreen Life Actin solid drink can improve the learning and memory impairment of dementia mice induced by scopolamine,and raspberry may play a major role in the formula.

关 键 词：筑青生命活素固体饮料 学习记忆障碍 覆盆子 东莨菪碱 

分 类 号：TS278[轻工技术与工程—农产品加工及贮藏工程] TS201.4[轻工技术与工程—食品科学与工程]