灵芝三萜的药理学研究进展  

Research on Pharmacology of Ganoderma Triterpenoids

作　　者：卢烽 姜涛[3] 杨宝学[1,2] LU Feng;JIANG Tao;YANG Baoxue(Department of Pharmacology,School of Basic Medical Sciences,Peking University,Beijing 100191,China;State Key Laboratory of Vascular Homeostasis and Remodeling,Beijing 100191,China;School of Basic Medical Sciences,Beihua University,Jilin 132013,China)

机构地区：[1]北京大学基础医学院药理学系,北京100191 [2]血管稳态与重构全国重点实验室,北京100191 [3]北华大学基础医学院,吉林132013

出　　处：《菌物研究》2024年第1期60-78,共19页Journal of Fungal Research

基　　金：国家自然科学基金资助项目(81974083,82273999,81620108029);北京市自然科学基金资助项目(7232249,7212151)。

摘　　要：灵芝是药食同源的大型真菌,可用于预防和治疗多种疾病。灵芝三萜是灵芝的重要活性成分,其含量是评价灵芝品质的重要指标。灵芝三萜的化学结构决定其多样的生物学活性,包括抗炎、抗氧化、抗肿瘤、抗衰老、调节免疫功能以及调节代谢等。文中基于相关研究文献对灵芝三萜的药理作用及其机制进行总结和论述,以期为灵芝三萜在创新药物研发与功能性食品开发领域的基础研究和转化应用提供系统参考资料。Ganoderma is a large fungus that has been used for a long time samely as medicines and cooking materials,just like a famous Chinese word of ancient wisdom"Yao-Shi-Tong-Yuan"saying that many edible foods are medicines because there is absolutely no clear classification among them,to prevent and treat various diseases.Triterpenoids are important bioactive components of Ganoderma,and their content is an important indicator for evaluating the quality of Ganoderma.The various chemical structures of Ganoderma triterpenoids determine their diversified biological activities,including anti-inflammatory,antioxidant,anti-tumor,anti-aging and regulation of immune functions and metabolism as well.On the basis of relevant research literatures,this article summarizes and discusses the pharmacological effects and functional mechanisms of Ganoderma triterpenoids,wishing to provide systematic and referent information for the future basic research and industrial application of Ganoderma triterpenoids in such fields as drug innovation and functional food development.

关 键 词：灵芝三萜 药理活性 功能性食品 灵芝酸 

分 类 号：R285[医药卫生—中药学] Q949.32[医药卫生—中医学]