江苏省农村地区居民食管癌及癌前病变影响因素分析  

Analysis of influencing factors of esophageal cancer and precancerous lesions in rural residents of Jiangsu province

作　　者：刘付东[1] 吴玲玲 缪伟刚 韩仁强[2] 苏健[2] 周金意[2] 罗鹏飞[2] LIU Fudong;WU Lingling;MIAO Weigang;HAN Renqiang;SU Jian;ZHOU Jinyi;LUO Pengfei(Department of Chronic Disease Prevention,Yancheng Center for Disease Control and Prevention,Yancheng 224002,China;Department of Noncommunicable Chronic Disease Prevention,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China)

机构地区：[1]盐城市疾病预防控制中心慢性病防制科,江苏盐城224100 [2]江苏省疾病预防控制中心慢性非传染病防制所,江苏南京210009

出　　处：《中国肿瘤外科杂志》2024年第2期116-121,共6页Chinese Journal of Surgical Oncology

基　　金：中国消化道早癌医师共同成长计划科研项目(GTCZ-2020-JS-32-0002);盐城市医学科技发展计划项目(YK2021033)。

摘　　要：目的了解江苏省农村地区居民食管癌及癌前病变检出情况及影响因素,为食管癌的预防提供理论依据。方法2017年1月至2022年12月“江苏省农村上消化道癌早诊早治”项目采用整群抽样的方法抽取40~69岁常住居民参与研究,选取其中51198名40~69岁居民作为调查对象,进行危险因素问卷调查、内镜检查和组织活检,根据病理诊断确定食管癌癌前病变或食管癌。采用SPSS 22.0软件进行χ^(2)检验。采用无序多分类Logistic回归分析食管癌前病变和食管癌的影响因素。结果51198名调查对象检出食管癌前病变1279例,检出率2.50%,食管癌741例,检出率1.45%。无序多分类Logistic回归分析结果显示,高中及以上教育水平(OR=0.81,95%CI:0.66~0.98)、家庭收入≥5万(OR=0.82,95%CI:0.73~0.93)和每周食用1~2次新鲜水果(OR=0.70,95%CI:0.52~0.93)是食管癌前病变低风险相关的因素;男性(OR=1.45,95%CI:1.27~1.65)、年龄(OR=5.35,95%CI:4.22~6.79)、食用腌晒食物(<2次/周:OR=1.80,95%CI:1.42~2.28;≥2次/周:OR=3.01,95%CI:2.35~3.87)、食管炎(OR=1.65,95%CI:1.19~2.31)和吃饭生气(OR=2.43,95%CI:2.07~2.85)是食管癌前病变高风险相关的因素。家庭收入≥5万(OR=0.74,95%CI:0.64~0.86)是食管癌低风险相关的因素;男性(OR=1.64,95%CI:1.38~1.95)、年龄(OR=5.54,95%CI:4.11~7.46)、每周食用1~2次霉变食物(OR=1.87,95%CI:1.38~2.54)、食管炎(OR=1.86,95%CI:1.22~2.86)和吃饭生气(OR=2.95,95%CI:2.37~3.67)是食管癌高风险相关的因素。结论江苏省农村地区居民食管癌及癌前病变检出率较高,应加强男性、高龄、有食管炎史和饮食习惯不良人群的食管癌健康知识宣传,以降低食管癌患病风险。Objective To investigate the detection and influencing factors of esophageal cancer and precancerous lesions in the rural areas of Jiangsu province,and provide theoretical basis for esophageal cancer prevention.Methods The permanent residents aged 40-69 years old who participated in the Early diagnosis and early treatment of upper digestive tract cancer in rural areas of Jiangsu province program from January 2017 to December 2022 were selected.A total of 51,198 residents aged 40-69 years old were selected as the research subjects.Risk factors questionnaire,endoscopy,and tissue biopsy were carried out to determine the precancerous lesions or esophageal cancer according to the pathological diagnosis.SPSS 22.0 software was used for chi-square test.Multinomial logistic regression was used to analyze the influencing factors of esophageal precancerous lesions and esophageal cancer.Results 1,279 cases of precancerous lesions and 741 cases of esophageal cancer were detected in 51,198 subjects(2.50%and 1.45%,respectively).Multinomial logistic regression analysis showed that high school education level or above(OR=0.81,95%CI:0.66~0.98),a household income of over 50,000 yuan(OR=0.82,95%CI:0.73~0.93),and eating fresh fruit once or twice a week(OR=0.70,95%CI:0.52~0.93)were low risk factors of esophageal precancerous lesions;Male(OR=1.45,95%CI:1.27~1.65),age(OR=5.35,95%CI:4.22~6.79),eating pickled food(<twice/week:OR=1.80,95%CI:1.42~2.28;≥twice/week:OR=3.01,95%CI:2.35~3.87),esophagitis(OR=1.65,95%CI:1.19~2.31)and geting angry during meals(OR=2.43,95%CI:2.07~2.85)were high risk factors of esophageal precancerous lesions;A household income of over 50000 yuan was a low risk factor of esophageal cancer(OR=0.74,95%CI:0.64~0.86),male(OR=1.64,95%CI:1.38~1.95),age(OR=5.54,95%CI:4.11~7.46),eating moldy food once or twice a week(OR=1.87,95%CI:1.38~2.54),sophagitis(OR=1.86,95%CI:1.22~2.86),and getting angry during meals(OR=2.95,95%CI:2.37~3.67)were high risk factors of esophageal cancer.Conclusions The detection rate of esophageal canc

关 键 词：食管癌 癌前病变 危险因素 无序多分类logistic回归分析 

分 类 号：R735.1[医药卫生—肿瘤]