2022年WHO头颈部肿瘤分类(第5版)的解读:口腔和舌体上皮性肿瘤  

Interpretation of the WHO 2022 classification of head and neck tumours(5th Edition):The epithelial tumours of oral cavity and mobile tongue

作　　者：李金薇 沙桐 郑凯娟 聂孟冬 关苇杭 史册[1] LI Jinwei;SHA Tong;ZHENG Kaijuan;NIE Mengdong;GUAN Weihang;SHI Ce(Department of Oral Pathology,Hospital of Stomatology,Jilin University,Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院口腔病理科,吉林省牙发育及颌骨重塑与再生重点实验室,长春130021

出　　处：《口腔颌面外科杂志》2024年第2期81-86,共6页Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(82270959、81970903);吉林大学白求恩计划项目(2023B28);中央高校基本科研业务费专项资金。

摘　　要：2022年3月,世界卫生组织(World Health Organization,WHO)发布了第5版《头颈部肿瘤分类》。第5版的口腔和舌体肿瘤部分中,上皮性肿瘤相较于2017年的第4版作出了一些修改,其中包括将口腔潜在恶性疾病(oral potentially malignant disorders,OPMD)和口腔上皮异常增生(oral epithelial dysplasia,OED)作了分开阐述,并详细讨论了黏膜下纤维性变(submucousfibrosis,SF)和人乳头瘤病毒(human papillomavirus,HPV)相关性口腔上皮异常增生(HPV-associated oral epithelial dysplasia,HPVOED);在鳞状细胞癌(squamous cell carcinoma,SCC)部分,介绍了穿掘性癌(carcinoma cuniculatum,CC)和疣状癌(verrucous carcinoma,VC),并阐述了其特有的临床和组织学特征。本文总结了自2017年来口腔和舌体的上皮性肿瘤相关内容在临床、组织学和分子学研究中的最新进展。The 5th edition of the Classification of Head and Neck Tumours by the World Health Organization(WHO)was published in March 2022.In the section on oral cavity and mobile tongue tumours,the classification of epithelial tumours in the 5th edition has undergone several modifications compared to the 4th edition published in 2017.Notably,oral potentially malignant disorders(OPMD)and oral epithelial dysplasia(OED)have been addressed separately,and in-depth discussions have been included regarding submucosal fibrosis(SF)and human papillomavirus(HPV)-associated oral epithelial dysplasia(HPVOED).Additionally,the section on squamous cell carcinoma(SCC)now includes carcinoma cuniculatum(CC)and verrucous carcinoma(VC),emphasizing their distinctive clinical and histological characteristics.This review provides a comprehensive overview of the most recent advancements in clinical,histological,and molecular research on epithelial tumours of oral cavity and mobile tongue since 2017.

关 键 词：世界卫生组织 口腔和舌体肿瘤 非肿瘤性病变 上皮性肿瘤 

分 类 号：R782[医药卫生—口腔医学] R739.8[医药卫生—临床医学]