预防性宫颈癌疫苗的研究现状  

Current Research Status of Preventive Cervical Cancer Vaccines

作　　者：孙莉[1] 肖玲 叶海辉 Sun Li;Xiao Ling;Ye Haihui(Xiangyang Polytechnic,Xiangyang Hubei 441050,China;Women’s Health Department of Meternal and Child Health Hospital of Xiangyang,Cervical Cancer Prevention and Treatment Center of Xiangyang,Xiangyang Hubei 441050,China;Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science,Xiangyang Hubei 441050,China)

机构地区：[1]襄阳职业技术学院,湖北襄阳441050 [2]襄阳市妇幼保健院妇保科,襄阳市宫颈癌防治中心,湖北襄阳441021 [3]湖北文理学院附属医院,襄阳市中心医院,湖北襄阳441021

出　　处：《襄阳职业技术学院学报》2024年第2期113-117,共5页Journal of Xiangyang Polytechnic

基　　金：2020年度湖北省教育厅科学研究计划指导性项目“‘精准医疗’背景下宫颈癌早期精准诊断的应用研究”(B2020399)。

摘　　要：宫颈癌是女性最常见的生殖系统恶性肿瘤,也是目前为止唯一病因明确、可防可治的恶性肿瘤。人乳头瘤病毒(human papillomavirus,HPV)的持续感染是导致宫颈癌的常见和重要因素,近十几年来全球针对宫颈癌的预防进行了多种HPV疫苗的开发和应用实践。2020年,世界卫生组织启动了加速消除宫颈癌全球战略,疫苗接种是消除宫颈癌一级预防的重要手段。文章对HPV与宫颈癌的关系进行了深入分析,并综述了当前国内外预防性宫颈癌疫苗的研发历程、作用机制与主要类型,为宫颈癌疫苗接种的实施提供一定参考依据。Cervical cancer is the most common malignant tumor of the female reproductive system,and it is also the only malignant tumor with clear etiology,prevention and treatment.The persistent infection of human papillomavirus(HPV)is a common and important factor leading to cervical cancer.In recent decades,a variety of HPV vaccines have been developed and applied globally for the prevention of cervical cancer.In 2020,the World Health Organization launched the Global Strategy to Accelerate the Elimination of Cervical Cancer,and vaccination is an important means to eliminate the primary prevention of cervical cancer.In this paper,the relationship between HPV and cervical cancer was analyzed in depth,and the current research and development process,mechanism of action and main types of preventive cervical cancer vaccine at home and abroad were reviewed,which provided some reference for the implementation of cervical cancer vaccination.

关 键 词：宫颈癌 疫苗 人乳头瘤病毒 机制 类型 

分 类 号：R737[医药卫生—肿瘤]