P21活化激酶4在胃肠道间质瘤中的表达及意义  

Expression and significance of P21-activated kinase 4 in gastrointestinal stromal tumor

作　　者：高福来[1] 赵东强[2] 谢长顺[1] 李莉[1] 胡宗晶 郑岳[1] GAO Fulai;ZHAO Dongqiang;XIE Changshun;LI Li;HU Zongjing;ZHENG Yue(Department of Gastroenterology,First Hospital of Qinhuangdao,Qinhuangdao 066000;Department of Gastroenterology,the Second Hospital of Hebei Medical University;Department of Gastroenterology,Affiliated Hospital of Jining Medical University,China)

机构地区：[1]秦皇岛市第一医院消化内科,河北秦皇岛066000 [2]河北医科大学第二医院消化内科 [3]济宁医学院附属医院消化内科

出　　处：《胃肠病学和肝病学杂志》2024年第4期372-374,380,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：河北省医学科学研究课题(20221609)。

摘　　要：目的通过研究不同危险度胃肠道间质瘤(gastrointestinal stromal tumor,GIST)中P21活化激酶4(P21-activated kinase 4,PAK4)的表达量,探讨PAK4与GIST危险度的关系。方法选取2020年10月至2021年4月秦皇岛市第一医院病理诊断为GIST患者24例,根据共识将患者分为高危组、中危组、低危组,通过病理切片来确定不同危险度组的PAK4的表达量,并根据Callow计算方法对不同危险度组进行评分。结果PAK4随着GIST危险度增加表达升高,并且与正常对照组织及瘤旁组织相比,GIST中的PAK4表达量升高。结论PAK4表达量与GIST危险度相关,并且随着危险度升高,表达量也升高。Objective To explore the relationship between P21-activated kinase 4(PAK4)and the risk of gastrointestinal stromal tumor(GIST),and to study the expression of PAK4 in GIST with different risk grade.Methods From Oct.2020 to Apr.2021,24 inpatients with GIST in the First Hospital of Qinhuangdao were selected.According to the risk grading evaluation method,the patients were divided into high-risk group,medium-risk group and low-risk group.The expressions of PAK4 in different risk groups were determined by pathological sections,and according to Callow calculation method.Results The expression PAK4 increased with the risk escalation of GIST,and the expression of PAK4 in GIST was higher than that in normal control tissues and adjacent tissues.Conclusion The expression level of PAK4 is related to the risk of GIST,and the expression level increases with the increase of the risk.

关 键 词：P21活化激酶4 胃肠道间质瘤 危险度 

分 类 号：R735.2[医药卫生—肿瘤]