胃癌组织中突触融合蛋白6的表达与临床病理特征及远期预后的相关性  

Correlation Between the Expression of Synaptic Fusion Protein 6 in Gastric Cancer Tissue and Clinical Pathological Features as well as Long-Term Prognosis

作　　者：王娜[1] 杨迷玲 杨金花 郝义彬 WANG Na;YANG Miling;YANG Jinhua;HAO Yibin(Department of Pathology,the Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine(Zhengzhou People’s Hospital),Zhengzhou 450053,China)

机构地区：[1]河南中医药大学第五临床医学院(郑州人民医院)病理科,河南郑州450053

出　　处：《河南医学研究》2024年第8期1381-1384,共4页Henan Medical Research

基　　金：河南省医学科技攻关计划省部共建项目(2018010043)。

摘　　要：目的分析胃癌组织突触融合蛋白6(STX6)表达与临床病理特征及远期预后的相关性。方法收集2019年6月至2022年6月在河南中医药大学第五临床医学院(郑州人民医院)的82例胃癌患者,采用免疫组织化学法检测STX6表达情况,采用χ2检验分析STX6与临床病理特征的相关性;随访至2023年6月,记录所有胃癌患者的生存结局,采用Pearson相关性分析胃癌组织中STX6表达与远期预后的相关性。结果胃癌组织STX6表达阳性率为65.85%,高于癌旁组织50.00%(P<0.05)。胃癌组织中STX6表达与肿瘤部位、肿瘤直径及分化程度无相关性(P>0.05),但与TNM分期、淋巴结转移及人类表皮生长因子受体-2(HER-2)有关(P<0.05)。经log-rank检验显示,STX6阳性表达者的总生存时间较STX6阴性表达者短(P<0.05)。经Pearson相关性分析显示,胃癌组织中STX6表达与患者总生存期呈负相关(r<0,P<0.05)。结论胃癌组织中STX6呈高表达,且胃癌患者临床病理特征和远期预后与STX6表达有关。Objective To analyze the correlation between the expression of synaptic fusion protein 6(STX6)in gastric cancer tissue and clinical pathological features as well as long-term prognosis.Methods From June 2019 to June 2022,a total of 82 patients with gastric cancer were collected from the Fifth Clinical College of Henan University of Traditional Chinese Medicine(Zhengzhou People’s Hospital).The expression of STX6 was detected by immunohistochemistry,and the correlation between STX6 and clinicopathological features was analyzed byχ2 test.The patients were followed up to June 2023,and the survival outcomes of all patients with gastric cancer were recorded.Pearson correlation was used to analyze the correlation between STX6 expression in gastric cancer tissues and long-term prognosis.Results The positive rate of STX6 expression in gastric cancer tissue was 65.85%,which was higher than 50.00%in adjacent tissues(P<0.05).The expression of STX6 in gastric cancer tissue was not correlated with tumor location,tumor diameter and degree of differentiation(P>0.05),but was related to TNM staging,lymph node metastasis and human epidermal growth factor receptor-2(HER-2)(P<0.05).Log-rank test showed that the total survival time of STX6 positive expression was shorter than that of STX6 negative expression(P<0.05).Pearson correlation analysis showed that the expression of STX6 in gastric cancer tissue was negatively correlated with the overall survival time of patients(r<0,P<0.05).Conclusion STX6 is highly expressed in gastric cancer tissue,and the clinical pathological characteristics and long-term prognosis of gastric cancer patients are related to STX6 expression.

关 键 词：胃癌 突触融合蛋白6 病理特征 预后 

分 类 号：R735.2[医药卫生—肿瘤]