网状Meta分析证据缺失偏倚风险评价工具ROB-MEN中文解读  

A Chinese introduction to risk of bias due to missing evidence in network meta-analysis(ROB-MEN)

作　　者：胡玉鹏 朱涛[1] 邓湘金 曾维[1] 陈金龙 汤炜[1] 刘畅 HU Yupeng;ZHU Tao;DENG Xiangjin;ZENG Wei;CHEN Jinlong;TANG Wei;LIU Chang(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial Surgery&"Medicine+Manufacturing"Center,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,P.R.China;Department of Information Management&Department of Dental Informatics&Department of Evidence-Based Dentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,P.R.China)

机构地区：[1]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院口腔颌面外科、四川大学“医学+制造”中心,成都610041 [2]四川大学华西口腔医院信息管理部、口腔医学信息学教研室、循证口腔医学教研室,成都610041

出　　处：《中国循证医学杂志》2024年第4期451-458,共8页Chinese Journal of Evidence-based Medicine

基　　金：四川大学华西口腔医学院交叉学科创新项目(编号:RD-03-202303);四川大学“医学+制造”中心探索项目;四川省自然科学基金项目(编号:2022NSFSC0639)。

摘　　要：研究结果的选择性不报告和发表偏倚影响系统评价和Meta分析的效度,进而影响临床决策的制定。目前缺乏严格的方法评价网状Meta分析证据缺失偏倚风险。本文介绍网状Meta分析证据缺失偏倚风险评价工具ROB-MEN的主要内容,包括其工具表格、操作过程以及相关信号问题等。ROB-MEN工具的关键内容是两两比较表和ROB-MEN表,可应用于干预措施多、网络结构复杂的网状Meta分析,避免偏倚风险评价过程耗时久且耗费大量人力物力。同时ROB-MEN具有逻辑清晰、细节严谨、可用性强等优点,是首个评价网状Meta分析证据缺失偏倚风险的工具,可为临床研究者提供权威参考,值得推广和应用。Selective non-reporting and publication bias of study results threaten the validity of systematic reviews and meta-analyses,thus affect clinical decision making.There are no rigorous methods to evaluate the risk of bias in network meta-analyses currently.This paper introduces the main contents of ROB-MEN(risk of bias due to missing evidence in network meta-analysis),including tables of the tool,operation process and signal questions.The pairwise comparisons table and the ROB-MEN table are the tool’s core.The ROB-MEN tool can be applied to very large and complex networks including lots of interventions to avoid time-consuming and labor-intensive process,and it has the advantages of clear logic,complete details and good applicability.It is the first tool used to evaluate the risk of bias due to missing evidence in network meta-analysis and is useful to researchers,thus being worth popularizing and applying.

关 键 词：证据缺失偏倚 发表偏倚 偏倚风险 系统评价 网状Meta分析 两两比较 

分 类 号：R-03[医药卫生]