HDAC3在认知功能障碍中的研究进展  

Research progress of HDAC3 in cognitive impairment

作　　者：蔡凌宇 刘媛媛[2] 任江滨 苏鸿 孙晓阳[1] Cai Lingyu;Liu Yuanyuan;Ren Jiangbin;Su Hong;Sun Xiaoyang(Neurosurgery,the Affiliated Huaian First People's Hospital of Nanjing Medical University,Huaian 223001,China;Department of Endocrinology,the Affiliated Huaian First People's Hospital of Nanjing Medical University,Huaian 223001,China)

机构地区：[1]南京医科大学附属淮安第一医院神经外科,223001 [2]南京医科大学附属淮安第一医院内分泌科,223001

出　　处：《神经疾病与精神卫生》2024年第4期272-276,共5页Journal of Neuroscience and Mental Health

基　　金：国家自然科学基金(82000475)。

摘　　要：组蛋白去乙酰化酶3(HDAC3)是与认知功能障碍相关的表观遗传负性调节因子,在杏仁核、海马和皮层等部位广泛表达。激活后的HDAC3具有神经毒性作用,负性调控认知和记忆的形成。本文对HDAC3在认知功能障碍中的作用机制进行综述,并探讨HDAC3抑制剂治疗的发展前景。Histone deacetylase 3(HDAC3)is an epigenetic negative regulatory factor associated with cognitive impairment,widely expressed in the amygdala,hippocampus,and cortex.The activated HDAC3 has neurotoxic effects and negatively regulates the formation of cognition and memory.This paper reviews the mechanism of HDAC3 in cognitive impairment and explores the development prospects of HDAC3 inhibitor therapy.

关 键 词：认知功能障碍 组蛋白乙酰化酶3 神经毒性 靶向抑制 综述 

分 类 号：R749.1[医药卫生—神经病学与精神病学]