乌梅丸对Hp阳性萎缩性胃炎的临床研究  

Clinical Study of Wumei Pill on Hp Positive Atrophic Gastritis*

作　　者：黄胜林[1] 陈锦锋[1] 邓健敏[1] 韩宇斌[1] 张魁[1] HUANG Sheng-lin;CHEN Jin-feng;DENG Jian-min;HAN Yu-bin;ZHANG Kui(Foshan Traditional Chinese Medicine Hospital Foshan,Guangdong Province,Foshan 528000)

机构地区：[1]广东省佛山市中医院,佛山528000

出　　处：《实用中西医结合临床》2024年第4期1-4,共4页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省佛山市卫生健康局医学科研课题(编号:20210443)。

摘　　要：目的:探讨幽门螺杆菌(Hp)阳性萎缩性胃炎患者采用乌梅丸治疗的应用效果。方法:选取2022年1~12月在佛山市中医院接受治疗的Hp阳性萎缩性胃炎患者100例,以随机数字表法分成治疗组(50例)与对照组(50例)。对照组采用四联根除Hp疗法治疗,治疗组采用乌梅丸联合四联根除Hp疗法治疗,比较两组Hp转阴情况、临床疗效、中医症候积分、胃镜及病理情况、胃蛋白酶原Ⅰ(PGⅠ)及胃蛋白酶原Ⅱ(PGⅡ)水平。结果:治疗组Hp转阴率(96.00%)较对照组(82.00%)更高(P<0.05);治疗组治疗总有效率(92.00%)较对照组(76.00%)更高(P<0.05);两组治疗后中医证候积分降低(P<0.05),且治疗组较对照组更低(P<0.05);两组治疗后胃镜及病理情况评分降低(P<0.05),但两组间比较,差异无统计学意义(P>0.05);两组治疗后PGⅠ、PGⅡ水平提高(P<0.05),且治疗组较对照组更高(P<0.05)。结论:乌梅丸应用于Hp阳性萎缩性胃炎患者中,能够促进Hp转阴情况、临床症状改善,促进临床疗效提高,改善胃黏膜萎缩情况,提高PGⅠ及PGⅡ水平。Objective:To explore the therapeutic effect of Wumei Pill on patients with Helicobacter pylori(Hp)positive atrophic gastritis.Methods:A total of 100 patients with Hp positive atrophic gastritis who were treated in Foshan Traditional Chinese Medicine Hospital from January to December 2022 were selected,and divided into the treatment group(50 cases)and the control group(50 cases)by random number table method.The control group was given quadruple Hp eradication therapy,and the treatment group was given Wumei Pill combined with quadruple Hp eradication therapy.The Hp conversion rate,clinical efficacy,traditional chinese medicine syndrome score,gastroscopy and pathological conditions,as well as the levels of pepsinogenⅠ(PGⅠ)and pepsinogenⅡ(PGⅡ)of the two groups were compared.Results:In comparision of the control group(82.00%),the Hp conversion rate of the treatment group(96.00%)was higher(P<0.05).In comparision of the control group(76.00%),the total effective rate of the treatment group(92.00%)was higher(P<0.05).After treatment,the traditional chinese medicine syndrome score in both groups were decreased(P<0.05),and in comparision of the control group,the treatment group was lower(P<0.05).After treatment,the scores of gastroscopy and pathological conditions in both groups were decreased(P<0.05),but there was no statistically significant difference between the two groups(P>0.05).After treatment,the levels of PGⅠand PGⅡin both groups were increased(P<0.05),and in comparision of the control group,the treatment group was higher(P<0.05).Conclusion:The application of Wumei Pill in patients with Hp positive atrophic gastritis can promote Hp negative condition,improve clinical symptoms,enhance clinical efficacy,improve gastric mucosal atrophy,and increase PGⅠand PGⅡlevels.

关 键 词：萎缩性胃炎 幽门螺杆菌 乌梅丸 

分 类 号：R573.3[医药卫生—消化系统]