基于“脑-肠轴”理论探讨疏肝理脾汤联合穴位埋线对肝郁脾虚型溃疡性结肠炎的疗效  

Exploring the Therapeutic Efficacy of Shuganlipi Decoction Combined with Acupoint Catgut Embedding Liver Depression and Spleen Deficiency Type Ulcerative Colitis Based on the Brain-Gut Axis

作　　者：章钰川 余绪超 肖慧荣[2] 吴娜 涂艳琴 ZHANG Yu-chuan;YU Xu-chao;XIAO Hui-rong;WU Na;TU Yan-qin(2021 Master's Degree Candidate,Jiangxi University of Chinese Medicine,Nanchang 330004;The Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006)

机构地区：[1]江西中医药大学,南昌330004 [2]江西中医药大学附属医院,南昌330006

出　　处：《实用中西医结合临床》2024年第5期6-9,34,共5页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金资助项目(编号:82160903);2023年度江西省中医药科技计划重点项目(编号:2023Z005);2023年度江西省中医药管理局科技计划项目(编号:2023A0128)。

摘　　要：目的从“脑-肠轴”角度分析疏肝理脾汤联合穴位埋线对肝郁脾虚型溃疡性结肠炎(UC)的疗效。方法选取2020年1月至2023年1月在江西中医药大学附属医院肛肠科住院的80例UC患者。按照随机数字表法分为观察组40例(予疏肝理脾汤口服以及穴位埋线治疗)与对照组40例(予美沙拉嗪肠溶片口服),观察比较两组治疗前后临床疗效、黏膜愈合率、中医证候评分、改良Mayo评分、脑肠肽指标。结果治疗后,观察组临床疗效、黏膜愈合率优于对照组(P<0.05);两组中医证候评分、改良Mayo评分均较前显著降低,且观察组优于对照组(P<0.01);观察组血清5-羟色胺、P物质均较前显著降低、血管活性肠肽较前升高,且观察组优于对照组(P<0.01)。两组均未发生明显不良反应。结论疏肝理脾汤联合穴位埋线治疗UC临床效果显著,能有效调节患者脑肠肽指标,减轻黏膜病变程度,提高生活质量。Objective Analyzing the therapeutic efficacy of Shuganlipi Decoction combined with acupoint catgut embedding on Liver Depression and Spleen Deficiency type ulcerative colitis from the perspective of brain gut axis..Methods 80 UC patients admitted to the Department of Gastroenterology at the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2020 to January 2023 were selected for the study.Patients were randomly divided into an observation group of 40 cases(treated with Shuganlipi Decoction orally and acupoint catgut embedding)and a control group of 40 cases(treated with Mesalazine Slow Release Tablets orally).Clinical efficacy,mucosal healing rate,traditional Chinese medicine syndrome score,modified Mayo score,and brain-gut peptide indicators were observed and compared before and after treatment in both groups.Results After treatment,the clinical efficacy and mucosal healing rate in the observation group were higher than those in the control group(P<0.05).Both groups showed a significant reduction in traditional Chinese medicine syndrome scores and modified Mayo scores after treatment and the observation group performed better than the control group(P<0.01).The serum levels of 5-HT and SP in the observation group exhibited a pronounced decrease compared to before treatment,while VIP levels increased significantly.The observation group performed better than the control group(P<0.01).No adverse reactions were observed in either group.Conclusion The combination of Shuganlipi Decoction and acupoint catgut embedding has a significant therapeutic effect,effectively regulating the brain-gut peptide levels in patients,reducing mucosal lesions,and enhancing the quality of life.

关 键 词：溃疡性结肠炎 疏肝理脾汤 穴位埋线 脑-肠轴 

分 类 号：R574.62[医药卫生—消化系统]